High-intensity infrasound effects on glucose metabolism in rats

Abstract Recent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic...

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Autores principales:	Gonçalo Martins Pereira, Madalena Santos, Sofia S. Pereira, Gonçalo Borrecho, Francisco Tortosa, José Brito, Diamantino Freitas, António Oliveira de Carvalho, Artur Águas, Maria João Oliveira, Pedro Oliveira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0fa50e15c5154b7c86bee7ec4cae07ca
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spelling	oai:doaj.org-article:0fa50e15c5154b7c86bee7ec4cae07ca2021-12-02T16:35:05ZHigh-intensity infrasound effects on glucose metabolism in rats10.1038/s41598-021-96796-52045-2322https://doaj.org/article/0fa50e15c5154b7c86bee7ec4cae07ca2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96796-5https://doaj.org/toc/2045-2322Abstract Recent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic islet morphology, muscle GLUT4 and plasma insulin and corticosterone levels. Normal and glucose intolerant wild-type Wistar rats were randomly divided in two groups: one group not exposed to HII and the other continuously exposed to HII. Animals were sacrificed at three timepoints of exposure (1, 6 or 12 weeks). An intraperitoneal glucose tolerance test was performed, blood samples were collected and the pancreas and the quadriceps femoris muscle were excised. Circulating insulin and corticosterone levels were determined and pancreatic and muscular tissue were routinely processed for histochemistry and immunohistochemistry with an anti-GLUT4 antibody. Animals exposed to HII had higher corticosterone levels than animals not exposed. No differences were found on insulin concerning HII exposure or glucose intolerance. Glucose intolerant animals had pancreatic islet fibrosis and no differences were found in GLUT4 ratio concerning HII exposure. In conclusion, we found that continuous exposure to HII increases stress hormone levels without inducing glucose intolerance in rats.Gonçalo Martins PereiraMadalena SantosSofia S. PereiraGonçalo BorrechoFrancisco TortosaJosé BritoDiamantino FreitasAntónio Oliveira de CarvalhoArtur ÁguasMaria João OliveiraPedro OliveiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gonçalo Martins Pereira Madalena Santos Sofia S. Pereira Gonçalo Borrecho Francisco Tortosa José Brito Diamantino Freitas António Oliveira de Carvalho Artur Águas Maria João Oliveira Pedro Oliveira High-intensity infrasound effects on glucose metabolism in rats
description	Abstract Recent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic islet morphology, muscle GLUT4 and plasma insulin and corticosterone levels. Normal and glucose intolerant wild-type Wistar rats were randomly divided in two groups: one group not exposed to HII and the other continuously exposed to HII. Animals were sacrificed at three timepoints of exposure (1, 6 or 12 weeks). An intraperitoneal glucose tolerance test was performed, blood samples were collected and the pancreas and the quadriceps femoris muscle were excised. Circulating insulin and corticosterone levels were determined and pancreatic and muscular tissue were routinely processed for histochemistry and immunohistochemistry with an anti-GLUT4 antibody. Animals exposed to HII had higher corticosterone levels than animals not exposed. No differences were found on insulin concerning HII exposure or glucose intolerance. Glucose intolerant animals had pancreatic islet fibrosis and no differences were found in GLUT4 ratio concerning HII exposure. In conclusion, we found that continuous exposure to HII increases stress hormone levels without inducing glucose intolerance in rats.
format	article
author	Gonçalo Martins Pereira Madalena Santos Sofia S. Pereira Gonçalo Borrecho Francisco Tortosa José Brito Diamantino Freitas António Oliveira de Carvalho Artur Águas Maria João Oliveira Pedro Oliveira
author_facet	Gonçalo Martins Pereira Madalena Santos Sofia S. Pereira Gonçalo Borrecho Francisco Tortosa José Brito Diamantino Freitas António Oliveira de Carvalho Artur Águas Maria João Oliveira Pedro Oliveira
author_sort	Gonçalo Martins Pereira
title	High-intensity infrasound effects on glucose metabolism in rats
title_short	High-intensity infrasound effects on glucose metabolism in rats
title_full	High-intensity infrasound effects on glucose metabolism in rats
title_fullStr	High-intensity infrasound effects on glucose metabolism in rats
title_full_unstemmed	High-intensity infrasound effects on glucose metabolism in rats
title_sort	high-intensity infrasound effects on glucose metabolism in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0fa50e15c5154b7c86bee7ec4cae07ca
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High-intensity infrasound effects on glucose metabolism in rats

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