Towards a functional understanding of protein N-terminal acetylation.

Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function...

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Autor principal:	Thomas Arnesen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0faccd58079e4e46ab83a328163896c2
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spelling	oai:doaj.org-article:0faccd58079e4e46ab83a328163896c22021-11-18T05:36:10ZTowards a functional understanding of protein N-terminal acetylation.1544-91731545-788510.1371/journal.pbio.1001074https://doaj.org/article/0faccd58079e4e46ab83a328163896c22011-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21655309/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come.Thomas ArnesenPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 9, Iss 5, p e1001074 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Thomas Arnesen Towards a functional understanding of protein N-terminal acetylation.
description	Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come.
format	article
author	Thomas Arnesen
author_facet	Thomas Arnesen
author_sort	Thomas Arnesen
title	Towards a functional understanding of protein N-terminal acetylation.
title_short	Towards a functional understanding of protein N-terminal acetylation.
title_full	Towards a functional understanding of protein N-terminal acetylation.
title_fullStr	Towards a functional understanding of protein N-terminal acetylation.
title_full_unstemmed	Towards a functional understanding of protein N-terminal acetylation.
title_sort	towards a functional understanding of protein n-terminal acetylation.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/0faccd58079e4e46ab83a328163896c2
work_keys_str_mv	AT thomasarnesen towardsafunctionalunderstandingofproteinnterminalacetylation
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Towards a functional understanding of protein N-terminal acetylation.

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