Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.

The emergence of the influenza (H1N1) 2009 virus provided a unique opportunity to study the evolution of a pandemic virus following its introduction into the human population. Virological and clinical surveillance in the UK were comprehensive during the first and second waves of the pandemic in 2009...

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Autores principales:	Monica Galiano, Paul-Michael Agapow, Catherine Thompson, Steven Platt, Anthony Underwood, Joanna Ellis, Richard Myers, Jonathan Green, Maria Zambon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0fb51b6029e544dd8db8bf7e74dc4f50
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spelling	oai:doaj.org-article:0fb51b6029e544dd8db8bf7e74dc4f502021-11-18T06:47:20ZEvolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.1932-620310.1371/journal.pone.0023779https://doaj.org/article/0fb51b6029e544dd8db8bf7e74dc4f502011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21887318/?tool=EBIhttps://doaj.org/toc/1932-6203The emergence of the influenza (H1N1) 2009 virus provided a unique opportunity to study the evolution of a pandemic virus following its introduction into the human population. Virological and clinical surveillance in the UK were comprehensive during the first and second waves of the pandemic in 2009, with extensive laboratory confirmation of infection allowing a detailed sampling of representative circulating viruses. We sequenced the complete coding region of the haemagglutinin (HA) segment of 685 H1N1 pandemic viruses selected without bias during two waves of pandemic in the UK (April-December 2009). Phylogenetic analysis showed that although temporal accumulation of amino acid changes was observed in the HA sequences, the overall diversity was less than that typically seen for seasonal influenza A H1N1 or H3N2. There was co-circulation of multiple variants as characterised by signature amino acid changes in the HA. A specific substitution (S203T) became predominant both in UK and global isolates. No antigenic drift occurred during 2009 as viruses with greater than four-fold reduction in their haemagglutination inhibition (HI) titre ("low reactors") were detected in a low proportion (3%) and occurred sporadically. Although some limited antigenic divergence in viruses with four-fold reduction in HI titre might be related to the presence of 203T, additional studies are needed to test this hypothesis.Monica GalianoPaul-Michael AgapowCatherine ThompsonSteven PlattAnthony UnderwoodJoanna EllisRichard MyersJonathan GreenMaria ZambonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23779 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Monica Galiano Paul-Michael Agapow Catherine Thompson Steven Platt Anthony Underwood Joanna Ellis Richard Myers Jonathan Green Maria Zambon Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.
description	The emergence of the influenza (H1N1) 2009 virus provided a unique opportunity to study the evolution of a pandemic virus following its introduction into the human population. Virological and clinical surveillance in the UK were comprehensive during the first and second waves of the pandemic in 2009, with extensive laboratory confirmation of infection allowing a detailed sampling of representative circulating viruses. We sequenced the complete coding region of the haemagglutinin (HA) segment of 685 H1N1 pandemic viruses selected without bias during two waves of pandemic in the UK (April-December 2009). Phylogenetic analysis showed that although temporal accumulation of amino acid changes was observed in the HA sequences, the overall diversity was less than that typically seen for seasonal influenza A H1N1 or H3N2. There was co-circulation of multiple variants as characterised by signature amino acid changes in the HA. A specific substitution (S203T) became predominant both in UK and global isolates. No antigenic drift occurred during 2009 as viruses with greater than four-fold reduction in their haemagglutination inhibition (HI) titre ("low reactors") were detected in a low proportion (3%) and occurred sporadically. Although some limited antigenic divergence in viruses with four-fold reduction in HI titre might be related to the presence of 203T, additional studies are needed to test this hypothesis.
format	article
author	Monica Galiano Paul-Michael Agapow Catherine Thompson Steven Platt Anthony Underwood Joanna Ellis Richard Myers Jonathan Green Maria Zambon
author_facet	Monica Galiano Paul-Michael Agapow Catherine Thompson Steven Platt Anthony Underwood Joanna Ellis Richard Myers Jonathan Green Maria Zambon
author_sort	Monica Galiano
title	Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.
title_short	Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.
title_full	Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.
title_fullStr	Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.
title_full_unstemmed	Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.
title_sort	evolutionary pathways of the pandemic influenza a (h1n1) 2009 in the uk.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/0fb51b6029e544dd8db8bf7e74dc4f50
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Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK.

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