Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic...
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Nature Portfolio
2019
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oai:doaj.org-article:0fb71062dc154a909e1831b9bf41223d2021-12-02T14:38:37ZDefective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis10.1038/s41467-019-11004-32041-1723https://doaj.org/article/0fb71062dc154a909e1831b9bf41223d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11004-3https://doaj.org/toc/2041-1723Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues.Josepmaria ArgemiMaria U. LatasaStephen R. AtkinsonIlya O. BlokhinVeronica MasseyJoel P. GueJoaquin CabezasJuan J. LozanoDerek Van BoovenAaron BellSheng CaoLawrence A. VernettiJuan P. ArabMeritxell Ventura-CotsLia R. EdmundsConstantino FondevillaPeter StärkelLaurent DubuquoyAlexandre LouvetGemma OdenaJuan L. GomezTomas AragonJose AltamiranoJuan CaballeriaMichael J. JurczakD. Lansing TaylorCarmen BerasainClaes WahlestedtSatdarshan P. MongaMarsha Y. MorganPau Sancho-BruPhilippe MathurinShinji FuruyaCarolin LacknerIvan RusynVijay H. ShahMark R. ThurszJelena MannMatias A. AvilaRamon BatallerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
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DOAJ |
| collection |
DOAJ |
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EN |
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Science Q Josepmaria Argemi Maria U. Latasa Stephen R. Atkinson Ilya O. Blokhin Veronica Massey Joel P. Gue Joaquin Cabezas Juan J. Lozano Derek Van Booven Aaron Bell Sheng Cao Lawrence A. Vernetti Juan P. Arab Meritxell Ventura-Cots Lia R. Edmunds Constantino Fondevilla Peter Stärkel Laurent Dubuquoy Alexandre Louvet Gemma Odena Juan L. Gomez Tomas Aragon Jose Altamirano Juan Caballeria Michael J. Jurczak D. Lansing Taylor Carmen Berasain Claes Wahlestedt Satdarshan P. Monga Marsha Y. Morgan Pau Sancho-Bru Philippe Mathurin Shinji Furuya Carolin Lackner Ivan Rusyn Vijay H. Shah Mark R. Thursz Jelena Mann Matias A. Avila Ramon Bataller Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis |
| description |
Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues. |
| format |
article |
| author |
Josepmaria Argemi Maria U. Latasa Stephen R. Atkinson Ilya O. Blokhin Veronica Massey Joel P. Gue Joaquin Cabezas Juan J. Lozano Derek Van Booven Aaron Bell Sheng Cao Lawrence A. Vernetti Juan P. Arab Meritxell Ventura-Cots Lia R. Edmunds Constantino Fondevilla Peter Stärkel Laurent Dubuquoy Alexandre Louvet Gemma Odena Juan L. Gomez Tomas Aragon Jose Altamirano Juan Caballeria Michael J. Jurczak D. Lansing Taylor Carmen Berasain Claes Wahlestedt Satdarshan P. Monga Marsha Y. Morgan Pau Sancho-Bru Philippe Mathurin Shinji Furuya Carolin Lackner Ivan Rusyn Vijay H. Shah Mark R. Thursz Jelena Mann Matias A. Avila Ramon Bataller |
| author_facet |
Josepmaria Argemi Maria U. Latasa Stephen R. Atkinson Ilya O. Blokhin Veronica Massey Joel P. Gue Joaquin Cabezas Juan J. Lozano Derek Van Booven Aaron Bell Sheng Cao Lawrence A. Vernetti Juan P. Arab Meritxell Ventura-Cots Lia R. Edmunds Constantino Fondevilla Peter Stärkel Laurent Dubuquoy Alexandre Louvet Gemma Odena Juan L. Gomez Tomas Aragon Jose Altamirano Juan Caballeria Michael J. Jurczak D. Lansing Taylor Carmen Berasain Claes Wahlestedt Satdarshan P. Monga Marsha Y. Morgan Pau Sancho-Bru Philippe Mathurin Shinji Furuya Carolin Lackner Ivan Rusyn Vijay H. Shah Mark R. Thursz Jelena Mann Matias A. Avila Ramon Bataller |
| author_sort |
Josepmaria Argemi |
| title |
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis |
| title_short |
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis |
| title_full |
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis |
| title_fullStr |
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis |
| title_full_unstemmed |
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis |
| title_sort |
defective hnf4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/0fb71062dc154a909e1831b9bf41223d |
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