Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents

Abstract In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its possible target i...

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Autores principales:	Jung-Jin Lee, Ji-Hye Lee, Nam-Hui Yim, Joo-Hui Han, Jin Yeul Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0fb962310daa431fa2b5f91b6a40955b
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spelling	oai:doaj.org-article:0fb962310daa431fa2b5f91b6a40955b2021-12-02T11:40:59ZApplication of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents10.1038/s41598-017-08410-22045-2322https://doaj.org/article/0fb962310daa431fa2b5f91b6a40955b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08410-2https://doaj.org/toc/2045-2322Abstract In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its possible target in vitro and in vivo. We found that Alpinia officinarum Hance (AO) extract efficiently inhibited VSMC proliferation by arresting the transition from the G0/G1 to the S phase via the up-regulation of p27KIP1 expression. Galangin (GA) was determined to be a significant component of this extract, with the same anti-proliferative activity as the raw extract. Immunoblotting and immunofluorescence staining showed that both the AO extract and GA targeted the up-regulation of p27KIP1 expression. Therefore, we next examined the effect of these compounds in a cuff-injured neointimal hyperplasia model in vivo. In this animal model, both the AO extract and GA completely suppressed the neointima formation, and this inhibitory effect was also demonstrated to target the up-regulation of p27KIP1, including the suppression of proliferating cell nuclear antigen expression. Our findings indicate that AO extract and GA have a potent anti-proliferative activity, targeting the up-regulation of p27 expression. Thus, GA may represent an alternative medicine for use in DES.Jung-Jin LeeJi-Hye LeeNam-Hui YimJoo-Hui HanJin Yeul MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung-Jin Lee Ji-Hye Lee Nam-Hui Yim Joo-Hui Han Jin Yeul Ma Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents
description	Abstract In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its possible target in vitro and in vivo. We found that Alpinia officinarum Hance (AO) extract efficiently inhibited VSMC proliferation by arresting the transition from the G0/G1 to the S phase via the up-regulation of p27KIP1 expression. Galangin (GA) was determined to be a significant component of this extract, with the same anti-proliferative activity as the raw extract. Immunoblotting and immunofluorescence staining showed that both the AO extract and GA targeted the up-regulation of p27KIP1 expression. Therefore, we next examined the effect of these compounds in a cuff-injured neointimal hyperplasia model in vivo. In this animal model, both the AO extract and GA completely suppressed the neointima formation, and this inhibitory effect was also demonstrated to target the up-regulation of p27KIP1, including the suppression of proliferating cell nuclear antigen expression. Our findings indicate that AO extract and GA have a potent anti-proliferative activity, targeting the up-regulation of p27 expression. Thus, GA may represent an alternative medicine for use in DES.
format	article
author	Jung-Jin Lee Ji-Hye Lee Nam-Hui Yim Joo-Hui Han Jin Yeul Ma
author_facet	Jung-Jin Lee Ji-Hye Lee Nam-Hui Yim Joo-Hui Han Jin Yeul Ma
author_sort	Jung-Jin Lee
title	Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents
title_short	Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents
title_full	Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents
title_fullStr	Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents
title_full_unstemmed	Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents
title_sort	application of galangin, an active component of alpinia officinarum hance (zingiberaceae), for use in drug-eluting stents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0fb962310daa431fa2b5f91b6a40955b
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Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents

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