Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral...

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Autores principales:	Iria Carballo-Carbajal, Ariadna Laguna, Jordi Romero-Giménez, Thais Cuadros, Jordi Bové, Marta Martinez-Vicente, Annabelle Parent, Marta Gonzalez-Sepulveda, Núria Peñuelas, Albert Torra, Beatriz Rodríguez-Galván, Andrea Ballabio, Takafumi Hasegawa, Analía Bortolozzi, Ellen Gelpi, Miquel Vila
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0fbc1ef6e5e046b1873667d6a11b3aa6
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spelling	oai:doaj.org-article:0fbc1ef6e5e046b1873667d6a11b3aa62021-12-02T17:01:51ZBrain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis10.1038/s41467-019-08858-y2041-1723https://doaj.org/article/0fbc1ef6e5e046b1873667d6a11b3aa62019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08858-yhttps://doaj.org/toc/2041-1723It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral dopaminergic neurons and is associated with a Parkinson’s disease phenotype when allowed to accumulate above a specific threshold.Iria Carballo-CarbajalAriadna LagunaJordi Romero-GiménezThais CuadrosJordi BovéMarta Martinez-VicenteAnnabelle ParentMarta Gonzalez-SepulvedaNúria PeñuelasAlbert TorraBeatriz Rodríguez-GalvánAndrea BallabioTakafumi HasegawaAnalía BortolozziEllen GelpiMiquel VilaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iria Carballo-Carbajal Ariadna Laguna Jordi Romero-Giménez Thais Cuadros Jordi Bové Marta Martinez-Vicente Annabelle Parent Marta Gonzalez-Sepulveda Núria Peñuelas Albert Torra Beatriz Rodríguez-Galván Andrea Ballabio Takafumi Hasegawa Analía Bortolozzi Ellen Gelpi Miquel Vila Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
description	It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral dopaminergic neurons and is associated with a Parkinson’s disease phenotype when allowed to accumulate above a specific threshold.
format	article
author	Iria Carballo-Carbajal Ariadna Laguna Jordi Romero-Giménez Thais Cuadros Jordi Bové Marta Martinez-Vicente Annabelle Parent Marta Gonzalez-Sepulveda Núria Peñuelas Albert Torra Beatriz Rodríguez-Galván Andrea Ballabio Takafumi Hasegawa Analía Bortolozzi Ellen Gelpi Miquel Vila
author_facet	Iria Carballo-Carbajal Ariadna Laguna Jordi Romero-Giménez Thais Cuadros Jordi Bové Marta Martinez-Vicente Annabelle Parent Marta Gonzalez-Sepulveda Núria Peñuelas Albert Torra Beatriz Rodríguez-Galván Andrea Ballabio Takafumi Hasegawa Analía Bortolozzi Ellen Gelpi Miquel Vila
author_sort	Iria Carballo-Carbajal
title	Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_short	Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_full	Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_fullStr	Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_full_unstemmed	Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
title_sort	brain tyrosinase overexpression implicates age-dependent neuromelanin production in parkinson’s disease pathogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0fbc1ef6e5e046b1873667d6a11b3aa6
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Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

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