Klotho deficiency intensifies hypoxia-induced expression of IFN-α/β through upregulation of RIG-I in kidneys.
Hypoxia is a common pathway to the progression of end-stage kidney disease. Retinoic acid-inducible gene I (RIG-I) encodes an RNA helicase that recognizes viruses including SARS-CoV2, which is responsible for the production of interferon (IFN)-α/β to prevent the spread of viral infection. Recently,...
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Autores principales: | Asako Urabe, Shigehiro Doi, Ayumu Nakashima, Takeshi Ike, Kenichi Morii, Kensuke Sasaki, Toshiki Doi, Koji Arihiro, Takao Masaki |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/0fbdc8bf39ef4ebf97e54d1a9a7eb769 |
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