ROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS

Abstract. A role of intracellular proteins of eosinophils and mast cells remains unclear in the patients with hematological neoplasia. There is a substantial evidence that eosinophils possess some common mechanisms of cooperation with mast cells. Therapeutic interventions into key events controlling...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L. S. Komarova, N. B. Mikhaylova, I. I. Nesterovich, Ye. Ye. Zueva, B. V. Afanasyev, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	ecp tryptase eosinophilia hematological neoplasia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0fbf69df1261476a89eef9e17d24880b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0fbf69df1261476a89eef9e17d24880b
record_format	dspace
spelling	oai:doaj.org-article:0fbf69df1261476a89eef9e17d24880b2021-11-18T08:03:39ZROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS1563-06252313-741X10.15789/1563-0625-2008-4-5-361-370https://doaj.org/article/0fbf69df1261476a89eef9e17d24880b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/192https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A role of intracellular proteins of eosinophils and mast cells remains unclear in the patients with hematological neoplasia. There is a substantial evidence that eosinophils possess some common mechanisms of cooperation with mast cells. Therapeutic interventions into key events controlling eosinophil migration may be a leading factor in treatment of hypereosinophylic states in onco-hematological disorders. Due to unknown functions of eosinophils in majority of eosinophilia-associated diseases, it would be useful to establish an algorithm of accurate diagnostics in the patients with eosinophilia, in order to choose more effective treatment in future.We studied serum levels of secretable eosinophil and mast cells proteins in oncohematological patients with increased eosinophil counts. The aim of our study was to test a significance of quantitative assay for tryptase and ECP in the patients with myelo- and lymphoproliferative diseases. The study group included thirty-eight patients with oncohematological diseases, accompanied by a marked eosinophilia (> 0.4 x 109/L). Eighteen patients with bronchial asthma (BA), and eight cases of solid tumors comprised a reference group for polyclonal eosinophilia. The levels of ECP and tryptase were measured in blood serum using a commercial fluoroimmunoenzyme assay («Pharmacia», Uppsala, Sweden). Total ECP levels were markedly increased in general group with hematological malignancies (p < 0.03), , and in cases of chronic GvHD (p < 0.03), and in a sub-group with lymphoproliferative disorders (р = 0.007) as compared to the group of non-hematological diseases.Serum levels of tryptase were significantly increased in the patients with chronic GvHD after allo-HSCT and lymphoproliferative diseases, as compared to the group of patients with solid tumors (р = 0.03), as well in GvHD compared with lymphoproliferative disorders (р < 0.05).A direct correlation was found between serum ECP levels and absolute eosinophil counts in peripheral blood for general hematological group (r = 0.51; р = 0.000001), and for a group of patients with lymphoproliferative diseases (r = 0.9; р = 0.000001). Hence, a quantitative determination of soluble eosinophylic proteins and mast cell-specific enzymes in blood serum are useful for diagnostics and monitoring of various hypereosinophilic conditions in oncohematological disorders. (Med. Immunol., vol. 10, N 4-5, pp 361-370).L. S. KomarovaN. B. MikhaylovaI. I. NesterovichYe. Ye. ZuevaB. V. AfanasyevAreg A. TotolianSPb RAACIarticleecptryptaseeosinophiliahematological neoplasiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 361-370 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	ecp tryptase eosinophilia hematological neoplasia Immunologic diseases. Allergy RC581-607
spellingShingle	ecp tryptase eosinophilia hematological neoplasia Immunologic diseases. Allergy RC581-607 L. S. Komarova N. B. Mikhaylova I. I. Nesterovich Ye. Ye. Zueva B. V. Afanasyev Areg A. Totolian ROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS
description	Abstract. A role of intracellular proteins of eosinophils and mast cells remains unclear in the patients with hematological neoplasia. There is a substantial evidence that eosinophils possess some common mechanisms of cooperation with mast cells. Therapeutic interventions into key events controlling eosinophil migration may be a leading factor in treatment of hypereosinophylic states in onco-hematological disorders. Due to unknown functions of eosinophils in majority of eosinophilia-associated diseases, it would be useful to establish an algorithm of accurate diagnostics in the patients with eosinophilia, in order to choose more effective treatment in future.We studied serum levels of secretable eosinophil and mast cells proteins in oncohematological patients with increased eosinophil counts. The aim of our study was to test a significance of quantitative assay for tryptase and ECP in the patients with myelo- and lymphoproliferative diseases. The study group included thirty-eight patients with oncohematological diseases, accompanied by a marked eosinophilia (> 0.4 x 109/L). Eighteen patients with bronchial asthma (BA), and eight cases of solid tumors comprised a reference group for polyclonal eosinophilia. The levels of ECP and tryptase were measured in blood serum using a commercial fluoroimmunoenzyme assay («Pharmacia», Uppsala, Sweden). Total ECP levels were markedly increased in general group with hematological malignancies (p < 0.03), , and in cases of chronic GvHD (p < 0.03), and in a sub-group with lymphoproliferative disorders (р = 0.007) as compared to the group of non-hematological diseases.Serum levels of tryptase were significantly increased in the patients with chronic GvHD after allo-HSCT and lymphoproliferative diseases, as compared to the group of patients with solid tumors (р = 0.03), as well in GvHD compared with lymphoproliferative disorders (р < 0.05).A direct correlation was found between serum ECP levels and absolute eosinophil counts in peripheral blood for general hematological group (r = 0.51; р = 0.000001), and for a group of patients with lymphoproliferative diseases (r = 0.9; р = 0.000001). Hence, a quantitative determination of soluble eosinophylic proteins and mast cell-specific enzymes in blood serum are useful for diagnostics and monitoring of various hypereosinophilic conditions in oncohematological disorders. (Med. Immunol., vol. 10, N 4-5, pp 361-370).
format	article
author	L. S. Komarova N. B. Mikhaylova I. I. Nesterovich Ye. Ye. Zueva B. V. Afanasyev Areg A. Totolian
author_facet	L. S. Komarova N. B. Mikhaylova I. I. Nesterovich Ye. Ye. Zueva B. V. Afanasyev Areg A. Totolian
author_sort	L. S. Komarova
title	ROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS
title_short	ROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS
title_full	ROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS
title_fullStr	ROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS
title_full_unstemmed	ROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS
title_sort	role of serum eosinophilic cationic protein and tryptase in myeloproliferative and lymphoproliferative disorders
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/0fbf69df1261476a89eef9e17d24880b
work_keys_str_mv	AT lskomarova roleofserumeosinophiliccationicproteinandtryptaseinmyeloproliferativeandlymphoproliferativedisorders AT nbmikhaylova roleofserumeosinophiliccationicproteinandtryptaseinmyeloproliferativeandlymphoproliferativedisorders AT iinesterovich roleofserumeosinophiliccationicproteinandtryptaseinmyeloproliferativeandlymphoproliferativedisorders AT yeyezueva roleofserumeosinophiliccationicproteinandtryptaseinmyeloproliferativeandlymphoproliferativedisorders AT bvafanasyev roleofserumeosinophiliccationicproteinandtryptaseinmyeloproliferativeandlymphoproliferativedisorders AT aregatotolian roleofserumeosinophiliccationicproteinandtryptaseinmyeloproliferativeandlymphoproliferativedisorders
_version_	1718422525147348992

ROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS

Ejemplares similares