Fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients

Antonio Carlos Maneira Godinho Netto,1,2 Túlio Gonçalves dos Reis,1,2 Cássia Franco Matheus,1,2 Beatriz Julião Vieira Aarestrup,3,4 Fernando Monteiro Aarestrup1,2,4 1School of Medical and Health Sciences – SUPREMA, 2Maternity Hospital Terezinha...

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Autores principales:	Godinho Netto AC, dos Reis TG, Matheus CF, Aarestrup BJ, Aarestrup FM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	asthma chronic obstructive pulmonary disease elderly patients nitric oxide Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/0fc1360035ab49b98c05f22908ffb1c4
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spelling	oai:doaj.org-article:0fc1360035ab49b98c05f22908ffb1c42021-12-02T02:36:12ZFraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients1178-1998https://doaj.org/article/0fc1360035ab49b98c05f22908ffb1c42016-05-01T00:00:00Zhttps://www.dovepress.com/fraction-of-exhaled-nitric-oxide-measurements-in-the-diagnoses-of-asth-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Antonio Carlos Maneira Godinho Netto,1,2 Túlio Gonçalves dos Reis,1,2 Cássia Franco Matheus,1,2 Beatriz Julião Vieira Aarestrup,3,4 Fernando Monteiro Aarestrup1,2,4 1School of Medical and Health Sciences – SUPREMA, 2Maternity Hospital Terezinha de Jesus, 3Morphology Department, Federal University of Juiz de Fora, Institute of Biological Sciences, 4Laboratory of Immunopathology and Experimental Pathology, Federal University of Juiz de Fora, Reproductive Biology Center (CBR), Juiz de Fora, Brazil Objective: To assess the value of fraction of exhaled nitric oxide (FeNO) measurements in the diagnosis of asthma in elderly patients. Methods: The clinical symptoms of 202 elderly patients were assessed with the asthma module of the International Study of Asthma and Allergies in Childhood test, which had been modified for the elderly patients, and the diagnostic routine for chronic obstructive pulmonary disease (COPD), which was based on the Global initiative for chronic Obstructive Lung Disease criteria. Of the 202 patients assessed, 43 were subjected to pulmonary function evaluations (spirometry) and FeNO measurements. Results: Of the 202 elderly patients, 34 had asthma (23 definite and eleven probable), 20 met COPD criteria, 13 presented with an overlap of asthma and COPD, and 135 did not fit the criteria for obstructive pulmonary disease. Among the 43 elderly patients who were subjected to FeNO measurements, ten showed altered results (23.2%) and 33 had normal results (76.7%). The average value of FeNO in patients with definite and probable asthma undergoing this procedure was 29.2 parts per billion whereas that in nonasthmatic patients was 17.5 parts per billion (P=0.0002). Conclusion: We show a clear relationship between FeNO levels and asthma symptoms and previous asthma diagnoses in elderly patients. Keywords: asthma, chronic obstructive pulmonary disease, elderly patients, nitric oxideGodinho Netto ACdos Reis TGMatheus CFAarestrup BJAarestrup FMDove Medical Pressarticleasthmachronic obstructive pulmonary diseaseelderly patientsnitric oxideGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 623-629 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	asthma chronic obstructive pulmonary disease elderly patients nitric oxide Geriatrics RC952-954.6
spellingShingle	asthma chronic obstructive pulmonary disease elderly patients nitric oxide Geriatrics RC952-954.6 Godinho Netto AC dos Reis TG Matheus CF Aarestrup BJ Aarestrup FM Fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients
description	Antonio Carlos Maneira Godinho Netto,1,2 Túlio Gonçalves dos Reis,1,2 Cássia Franco Matheus,1,2 Beatriz Julião Vieira Aarestrup,3,4 Fernando Monteiro Aarestrup1,2,4 1School of Medical and Health Sciences – SUPREMA, 2Maternity Hospital Terezinha de Jesus, 3Morphology Department, Federal University of Juiz de Fora, Institute of Biological Sciences, 4Laboratory of Immunopathology and Experimental Pathology, Federal University of Juiz de Fora, Reproductive Biology Center (CBR), Juiz de Fora, Brazil Objective: To assess the value of fraction of exhaled nitric oxide (FeNO) measurements in the diagnosis of asthma in elderly patients. Methods: The clinical symptoms of 202 elderly patients were assessed with the asthma module of the International Study of Asthma and Allergies in Childhood test, which had been modified for the elderly patients, and the diagnostic routine for chronic obstructive pulmonary disease (COPD), which was based on the Global initiative for chronic Obstructive Lung Disease criteria. Of the 202 patients assessed, 43 were subjected to pulmonary function evaluations (spirometry) and FeNO measurements. Results: Of the 202 elderly patients, 34 had asthma (23 definite and eleven probable), 20 met COPD criteria, 13 presented with an overlap of asthma and COPD, and 135 did not fit the criteria for obstructive pulmonary disease. Among the 43 elderly patients who were subjected to FeNO measurements, ten showed altered results (23.2%) and 33 had normal results (76.7%). The average value of FeNO in patients with definite and probable asthma undergoing this procedure was 29.2 parts per billion whereas that in nonasthmatic patients was 17.5 parts per billion (P=0.0002). Conclusion: We show a clear relationship between FeNO levels and asthma symptoms and previous asthma diagnoses in elderly patients. Keywords: asthma, chronic obstructive pulmonary disease, elderly patients, nitric oxide
format	article
author	Godinho Netto AC dos Reis TG Matheus CF Aarestrup BJ Aarestrup FM
author_facet	Godinho Netto AC dos Reis TG Matheus CF Aarestrup BJ Aarestrup FM
author_sort	Godinho Netto AC
title	Fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients
title_short	Fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients
title_full	Fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients
title_fullStr	Fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients
title_full_unstemmed	Fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients
title_sort	fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0fc1360035ab49b98c05f22908ffb1c4
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Fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients

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