IMPACT OF MECHANICAL MYOCARDIAL INJURY PRODUCTS, LPS AND THEIR COMBINATION ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

Complicated systemic inflammatory response (SIR) often determines the outcome in patients after cardiac surgery. Systemic endothelial activation plays the most important role in SIR pathogenesis. We have studied the impact of mechanical myocardial injury products, LPS and their combination on human...

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Autores principales:	V. G. Matveeva, A. S. Golovkin, L. V. Antonova, I. V. Kudryavtsev, S. V. Ivanov, E. V. Grigoriev, N. V. Artymuk, A. G. Trishkin, E. S. Bikmetova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	endothelial cells pathogens products of damaged cells cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0fc48d8036d94d179d57fefe4696e8e0
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spelling	oai:doaj.org-article:0fc48d8036d94d179d57fefe4696e8e02021-11-18T08:03:44ZIMPACT OF MECHANICAL MYOCARDIAL INJURY PRODUCTS, LPS AND THEIR COMBINATION ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS1563-06252313-741X10.15789/1563-0625-2014-4-361-366https://doaj.org/article/0fc48d8036d94d179d57fefe4696e8e02014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/702https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XComplicated systemic inflammatory response (SIR) often determines the outcome in patients after cardiac surgery. Systemic endothelial activation plays the most important role in SIR pathogenesis. We have studied the impact of mechanical myocardial injury products, LPS and their combination on human umbilical vein endothelial cells (HUVEC). We have found that HUVEC increase the production of proinflammatory cytokines in response tocardiomyocyte cytosolic fraction responsible for mechanical injury modeling. 2% cytosolic fraction containing 0.204 ng/mL of Hsp70 was a greater stimulus for endothelial cells to produce IL-6 and IL8 than moderateendotoxin concentrations.V. G. MatveevaA. S. GolovkinL. V. AntonovaI. V. KudryavtsevS. V. IvanovE. V. GrigorievN. V. ArtymukA. G. TrishkinE. S. BikmetovaSPb RAACIarticleendothelial cellspathogensproducts of damaged cellscytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 4, Pp 361-366 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	endothelial cells pathogens products of damaged cells cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	endothelial cells pathogens products of damaged cells cytokines Immunologic diseases. Allergy RC581-607 V. G. Matveeva A. S. Golovkin L. V. Antonova I. V. Kudryavtsev S. V. Ivanov E. V. Grigoriev N. V. Artymuk A. G. Trishkin E. S. Bikmetova IMPACT OF MECHANICAL MYOCARDIAL INJURY PRODUCTS, LPS AND THEIR COMBINATION ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
description	Complicated systemic inflammatory response (SIR) often determines the outcome in patients after cardiac surgery. Systemic endothelial activation plays the most important role in SIR pathogenesis. We have studied the impact of mechanical myocardial injury products, LPS and their combination on human umbilical vein endothelial cells (HUVEC). We have found that HUVEC increase the production of proinflammatory cytokines in response tocardiomyocyte cytosolic fraction responsible for mechanical injury modeling. 2% cytosolic fraction containing 0.204 ng/mL of Hsp70 was a greater stimulus for endothelial cells to produce IL-6 and IL8 than moderateendotoxin concentrations.
format	article
author	V. G. Matveeva A. S. Golovkin L. V. Antonova I. V. Kudryavtsev S. V. Ivanov E. V. Grigoriev N. V. Artymuk A. G. Trishkin E. S. Bikmetova
author_facet	V. G. Matveeva A. S. Golovkin L. V. Antonova I. V. Kudryavtsev S. V. Ivanov E. V. Grigoriev N. V. Artymuk A. G. Trishkin E. S. Bikmetova
author_sort	V. G. Matveeva
title	IMPACT OF MECHANICAL MYOCARDIAL INJURY PRODUCTS, LPS AND THEIR COMBINATION ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
title_short	IMPACT OF MECHANICAL MYOCARDIAL INJURY PRODUCTS, LPS AND THEIR COMBINATION ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
title_full	IMPACT OF MECHANICAL MYOCARDIAL INJURY PRODUCTS, LPS AND THEIR COMBINATION ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
title_fullStr	IMPACT OF MECHANICAL MYOCARDIAL INJURY PRODUCTS, LPS AND THEIR COMBINATION ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
title_full_unstemmed	IMPACT OF MECHANICAL MYOCARDIAL INJURY PRODUCTS, LPS AND THEIR COMBINATION ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
title_sort	impact of mechanical myocardial injury products, lps and their combination on human umbilical vein endothelial cells
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/0fc48d8036d94d179d57fefe4696e8e0
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IMPACT OF MECHANICAL MYOCARDIAL INJURY PRODUCTS, LPS AND THEIR COMBINATION ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

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