DCE-MRI Background Parenchymal Enhancement Quantified from an Early versus Delayed Post-contrast Sequence: Association with Breast Cancer Presence

Abstract We investigated automated quantitative measures of background parenchymal enhancement (BPE) derived from an early versus delayed post-contrast sequence in breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for association with breast cancer presence in a case-control stud...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Shandong Wu, Margarita L. Zuley, Wendie A. Berg, Brenda F. Kurland, Rachel C. Jankowitz, Jules H. Sumkin, David Gur
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
R
Q
Acceso en línea:https://doaj.org/article/0fc6e5f900db4c54bca41bac404c6e70
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:0fc6e5f900db4c54bca41bac404c6e70
record_format dspace
spelling oai:doaj.org-article:0fc6e5f900db4c54bca41bac404c6e702021-12-02T12:32:57ZDCE-MRI Background Parenchymal Enhancement Quantified from an Early versus Delayed Post-contrast Sequence: Association with Breast Cancer Presence10.1038/s41598-017-02341-82045-2322https://doaj.org/article/0fc6e5f900db4c54bca41bac404c6e702017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02341-8https://doaj.org/toc/2045-2322Abstract We investigated automated quantitative measures of background parenchymal enhancement (BPE) derived from an early versus delayed post-contrast sequence in breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for association with breast cancer presence in a case-control study. DCE-MRIs were retrospectively analyzed for 51 cancer cases and 51 controls with biopsy-proven benign lesions, matched by age and year-of-MRI. BPE was quantified using fully-automated validated computer algorithms, separately from three sequential DCE-MRI post-contrast-subtracted sequences (SUB1, SUB2, and SUB3). The association of BPE computed from the three SUBs and other known factors with breast cancer were assessed in terms of odds ratio (OR) and area under the receiver operating characteristic curve (AUC). The OR of breast cancer for the percentage BPE measure (BPE%) quantified from SUB1 was 3.5 (95% Confidence Interval: 1.3, 9.8; p = 0.015) for 20% increments. Slightly lower and statistically significant ORs were also obtained for BPE quantified from SUB2 and SUB3. There was no significant difference (p > 0.2) in AUC for BPE quantified from the three post-contrast sequences and their combination. Our study showed that quantitative measures of BPE are associated with breast cancer presence and the association was similar across three breast DCE-MRI post-contrast sequences.Shandong WuMargarita L. ZuleyWendie A. BergBrenda F. KurlandRachel C. JankowitzJules H. SumkinDavid GurNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Shandong Wu
Margarita L. Zuley
Wendie A. Berg
Brenda F. Kurland
Rachel C. Jankowitz
Jules H. Sumkin
David Gur
DCE-MRI Background Parenchymal Enhancement Quantified from an Early versus Delayed Post-contrast Sequence: Association with Breast Cancer Presence
description Abstract We investigated automated quantitative measures of background parenchymal enhancement (BPE) derived from an early versus delayed post-contrast sequence in breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for association with breast cancer presence in a case-control study. DCE-MRIs were retrospectively analyzed for 51 cancer cases and 51 controls with biopsy-proven benign lesions, matched by age and year-of-MRI. BPE was quantified using fully-automated validated computer algorithms, separately from three sequential DCE-MRI post-contrast-subtracted sequences (SUB1, SUB2, and SUB3). The association of BPE computed from the three SUBs and other known factors with breast cancer were assessed in terms of odds ratio (OR) and area under the receiver operating characteristic curve (AUC). The OR of breast cancer for the percentage BPE measure (BPE%) quantified from SUB1 was 3.5 (95% Confidence Interval: 1.3, 9.8; p = 0.015) for 20% increments. Slightly lower and statistically significant ORs were also obtained for BPE quantified from SUB2 and SUB3. There was no significant difference (p > 0.2) in AUC for BPE quantified from the three post-contrast sequences and their combination. Our study showed that quantitative measures of BPE are associated with breast cancer presence and the association was similar across three breast DCE-MRI post-contrast sequences.
format article
author Shandong Wu
Margarita L. Zuley
Wendie A. Berg
Brenda F. Kurland
Rachel C. Jankowitz
Jules H. Sumkin
David Gur
author_facet Shandong Wu
Margarita L. Zuley
Wendie A. Berg
Brenda F. Kurland
Rachel C. Jankowitz
Jules H. Sumkin
David Gur
author_sort Shandong Wu
title DCE-MRI Background Parenchymal Enhancement Quantified from an Early versus Delayed Post-contrast Sequence: Association with Breast Cancer Presence
title_short DCE-MRI Background Parenchymal Enhancement Quantified from an Early versus Delayed Post-contrast Sequence: Association with Breast Cancer Presence
title_full DCE-MRI Background Parenchymal Enhancement Quantified from an Early versus Delayed Post-contrast Sequence: Association with Breast Cancer Presence
title_fullStr DCE-MRI Background Parenchymal Enhancement Quantified from an Early versus Delayed Post-contrast Sequence: Association with Breast Cancer Presence
title_full_unstemmed DCE-MRI Background Parenchymal Enhancement Quantified from an Early versus Delayed Post-contrast Sequence: Association with Breast Cancer Presence
title_sort dce-mri background parenchymal enhancement quantified from an early versus delayed post-contrast sequence: association with breast cancer presence
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/0fc6e5f900db4c54bca41bac404c6e70
work_keys_str_mv AT shandongwu dcemribackgroundparenchymalenhancementquantifiedfromanearlyversusdelayedpostcontrastsequenceassociationwithbreastcancerpresence
AT margaritalzuley dcemribackgroundparenchymalenhancementquantifiedfromanearlyversusdelayedpostcontrastsequenceassociationwithbreastcancerpresence
AT wendieaberg dcemribackgroundparenchymalenhancementquantifiedfromanearlyversusdelayedpostcontrastsequenceassociationwithbreastcancerpresence
AT brendafkurland dcemribackgroundparenchymalenhancementquantifiedfromanearlyversusdelayedpostcontrastsequenceassociationwithbreastcancerpresence
AT rachelcjankowitz dcemribackgroundparenchymalenhancementquantifiedfromanearlyversusdelayedpostcontrastsequenceassociationwithbreastcancerpresence
AT juleshsumkin dcemribackgroundparenchymalenhancementquantifiedfromanearlyversusdelayedpostcontrastsequenceassociationwithbreastcancerpresence
AT davidgur dcemribackgroundparenchymalenhancementquantifiedfromanearlyversusdelayedpostcontrastsequenceassociationwithbreastcancerpresence
_version_ 1718393900985483264