The mutational landscape of a prion-like domain

TDP43 aggregates are a hallmark of amyotrophic lateral sclerosis. By using deep mutagenesis to measure the toxicity of more than 50,000 mutations in the prion domain of TDP43, the authors conclude that mutations that increase toxicity promote formation of liquid-like condensates, while aggregation o...

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Autores principales:	Benedetta Bolognesi, Andre J. Faure, Mireia Seuma, Jörn M. Schmiedel, Gian Gaetano Tartaglia, Ben Lehner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0fca2a044c88458bacfb8b409c6af5b7
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spelling	oai:doaj.org-article:0fca2a044c88458bacfb8b409c6af5b72021-12-02T15:35:06ZThe mutational landscape of a prion-like domain10.1038/s41467-019-12101-z2041-1723https://doaj.org/article/0fca2a044c88458bacfb8b409c6af5b72019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12101-zhttps://doaj.org/toc/2041-1723TDP43 aggregates are a hallmark of amyotrophic lateral sclerosis. By using deep mutagenesis to measure the toxicity of more than 50,000 mutations in the prion domain of TDP43, the authors conclude that mutations that increase toxicity promote formation of liquid-like condensates, while aggregation of TDP43 is protective for the cell.Benedetta BolognesiAndre J. FaureMireia SeumaJörn M. SchmiedelGian Gaetano TartagliaBen LehnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benedetta Bolognesi Andre J. Faure Mireia Seuma Jörn M. Schmiedel Gian Gaetano Tartaglia Ben Lehner The mutational landscape of a prion-like domain
description	TDP43 aggregates are a hallmark of amyotrophic lateral sclerosis. By using deep mutagenesis to measure the toxicity of more than 50,000 mutations in the prion domain of TDP43, the authors conclude that mutations that increase toxicity promote formation of liquid-like condensates, while aggregation of TDP43 is protective for the cell.
format	article
author	Benedetta Bolognesi Andre J. Faure Mireia Seuma Jörn M. Schmiedel Gian Gaetano Tartaglia Ben Lehner
author_facet	Benedetta Bolognesi Andre J. Faure Mireia Seuma Jörn M. Schmiedel Gian Gaetano Tartaglia Ben Lehner
author_sort	Benedetta Bolognesi
title	The mutational landscape of a prion-like domain
title_short	The mutational landscape of a prion-like domain
title_full	The mutational landscape of a prion-like domain
title_fullStr	The mutational landscape of a prion-like domain
title_full_unstemmed	The mutational landscape of a prion-like domain
title_sort	mutational landscape of a prion-like domain
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0fca2a044c88458bacfb8b409c6af5b7
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The mutational landscape of a prion-like domain

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