Mechanism of pore opening in the calcium-activated chloride channel TMEM16A

The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. Here authors combine electrophysiology and autocorrelation analysis to observe the sampling of intermediate conformations during gating.

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Detalles Bibliográficos
Autores principales:	Andy K. M. Lam, Raimund Dutzler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0fcb6ff7244a49a3bb6ea4d49b731975
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spelling	oai:doaj.org-article:0fcb6ff7244a49a3bb6ea4d49b7319752021-12-02T14:06:28ZMechanism of pore opening in the calcium-activated chloride channel TMEM16A10.1038/s41467-020-20788-82041-1723https://doaj.org/article/0fcb6ff7244a49a3bb6ea4d49b7319752021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20788-8https://doaj.org/toc/2041-1723The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. Here authors combine electrophysiology and autocorrelation analysis to observe the sampling of intermediate conformations during gating.Andy K. M. LamRaimund DutzlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andy K. M. Lam Raimund Dutzler Mechanism of pore opening in the calcium-activated chloride channel TMEM16A
description	The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. Here authors combine electrophysiology and autocorrelation analysis to observe the sampling of intermediate conformations during gating.
format	article
author	Andy K. M. Lam Raimund Dutzler
author_facet	Andy K. M. Lam Raimund Dutzler
author_sort	Andy K. M. Lam
title	Mechanism of pore opening in the calcium-activated chloride channel TMEM16A
title_short	Mechanism of pore opening in the calcium-activated chloride channel TMEM16A
title_full	Mechanism of pore opening in the calcium-activated chloride channel TMEM16A
title_fullStr	Mechanism of pore opening in the calcium-activated chloride channel TMEM16A
title_full_unstemmed	Mechanism of pore opening in the calcium-activated chloride channel TMEM16A
title_sort	mechanism of pore opening in the calcium-activated chloride channel tmem16a
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0fcb6ff7244a49a3bb6ea4d49b731975
work_keys_str_mv	AT andykmlam mechanismofporeopeninginthecalciumactivatedchloridechanneltmem16a AT raimunddutzler mechanismofporeopeninginthecalciumactivatedchloridechanneltmem16a
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Mechanism of pore opening in the calcium-activated chloride channel TMEM16A

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