Bone Regeneration in the Application of a New Device for Osteosynthesis in the Experiment

Background. Treatment of residual cavities after radical surgery for bone diseases is a vital problem of modern traumatology. Currently, there is an active search for devices both for osteosynthesis and bone-substituting masses. Aims. The purpose of this work was to test a new device for osteosynthe...

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Autores principales:	Dmitriy I. Suchkov, Artem V. Pavlov, Aleksandr A. Vinogradov, Svetlana R. Zherebyatyeva, Vasiliy E. Timofeev, Galina S. Lazutina, Natalya V. Ovchinnikova, Viktoria N. Tarasova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	osteosynthesis bone defects plates wire cerclage osteogenesis Science Q
Acceso en línea:	https://doaj.org/article/0fcbdb77548a40c1933f5d2f86f56346
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spelling	oai:doaj.org-article:0fcbdb77548a40c1933f5d2f86f563462021-11-23T06:14:42ZBone Regeneration in the Application of a New Device for Osteosynthesis in the Experiment2541-94202587-959610.29413/ABS.2019-4.1.24https://doaj.org/article/0fcbdb77548a40c1933f5d2f86f563462019-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1995https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Treatment of residual cavities after radical surgery for bone diseases is a vital problem of modern traumatology. Currently, there is an active search for devices both for osteosynthesis and bone-substituting masses. Aims. The purpose of this work was to test a new device for osteosynthesis. It can be used both for fixing bone fragments, and for studying the morphological features of bone regenerate in experiment.Materials and methods. A device for bone osteosynthesis of tubular bones in an experiment (Patent of the Russian Federation N 20116121487) was applied. The device consisted of two half-bushings, fastened to each other by a fierce clamp. Polypropylene was used as the material for the half-bushings, therefore no immunological reactions were observed. On the inner surface there were silicone cylinders, which directed pressure on the fragments and did not disturb the nutrition of the periosteum. The experiment was performed on Wistar rats. The surgical defect of the femur was filled with hydroxyapatite. Two groups of animals were identified. The bone in the first group was fixed by the device. The wire cerclage was used in the second group.Results. The study showed that the developed device does not disturb the nutrition of the periosteum, and also tightly fixes the osteoplastic material in the bone defect. Histological examination showed that bone regeneration was faster when the device was used. On the 21st day of the experiment, the regenerate filled the defect in the control group by 62 %, and in the experimental group by 73 %. The regenerate was represented by a woven bone. In all animals, bone regenerate formed a strong osteo-integrative connection with the maternal bone. In both groups, it looked like a mature bone tissue at the end of the experiment (28 days).Conclusion. The data indicate that the device does not disturb the processes of bone formation and allows for more efficient use osteoplastic material.Dmitriy I. SuchkovArtem V. PavlovAleksandr A. VinogradovSvetlana R. ZherebyatyevaVasiliy E. TimofeevGalina S. LazutinaNatalya V. OvchinnikovaViktoria N. TarasovaScientific Сentre for Family Health and Human Reproduction Problemsarticleosteosynthesisbone defectsplateswire cerclageosteogenesisScienceQRUActa Biomedica Scientifica, Vol 4, Iss 1, Pp 155-161 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	osteosynthesis bone defects plates wire cerclage osteogenesis Science Q
spellingShingle	osteosynthesis bone defects plates wire cerclage osteogenesis Science Q Dmitriy I. Suchkov Artem V. Pavlov Aleksandr A. Vinogradov Svetlana R. Zherebyatyeva Vasiliy E. Timofeev Galina S. Lazutina Natalya V. Ovchinnikova Viktoria N. Tarasova Bone Regeneration in the Application of a New Device for Osteosynthesis in the Experiment
description	Background. Treatment of residual cavities after radical surgery for bone diseases is a vital problem of modern traumatology. Currently, there is an active search for devices both for osteosynthesis and bone-substituting masses. Aims. The purpose of this work was to test a new device for osteosynthesis. It can be used both for fixing bone fragments, and for studying the morphological features of bone regenerate in experiment.Materials and methods. A device for bone osteosynthesis of tubular bones in an experiment (Patent of the Russian Federation N 20116121487) was applied. The device consisted of two half-bushings, fastened to each other by a fierce clamp. Polypropylene was used as the material for the half-bushings, therefore no immunological reactions were observed. On the inner surface there were silicone cylinders, which directed pressure on the fragments and did not disturb the nutrition of the periosteum. The experiment was performed on Wistar rats. The surgical defect of the femur was filled with hydroxyapatite. Two groups of animals were identified. The bone in the first group was fixed by the device. The wire cerclage was used in the second group.Results. The study showed that the developed device does not disturb the nutrition of the periosteum, and also tightly fixes the osteoplastic material in the bone defect. Histological examination showed that bone regeneration was faster when the device was used. On the 21st day of the experiment, the regenerate filled the defect in the control group by 62 %, and in the experimental group by 73 %. The regenerate was represented by a woven bone. In all animals, bone regenerate formed a strong osteo-integrative connection with the maternal bone. In both groups, it looked like a mature bone tissue at the end of the experiment (28 days).Conclusion. The data indicate that the device does not disturb the processes of bone formation and allows for more efficient use osteoplastic material.
format	article
author	Dmitriy I. Suchkov Artem V. Pavlov Aleksandr A. Vinogradov Svetlana R. Zherebyatyeva Vasiliy E. Timofeev Galina S. Lazutina Natalya V. Ovchinnikova Viktoria N. Tarasova
author_facet	Dmitriy I. Suchkov Artem V. Pavlov Aleksandr A. Vinogradov Svetlana R. Zherebyatyeva Vasiliy E. Timofeev Galina S. Lazutina Natalya V. Ovchinnikova Viktoria N. Tarasova
author_sort	Dmitriy I. Suchkov
title	Bone Regeneration in the Application of a New Device for Osteosynthesis in the Experiment
title_short	Bone Regeneration in the Application of a New Device for Osteosynthesis in the Experiment
title_full	Bone Regeneration in the Application of a New Device for Osteosynthesis in the Experiment
title_fullStr	Bone Regeneration in the Application of a New Device for Osteosynthesis in the Experiment
title_full_unstemmed	Bone Regeneration in the Application of a New Device for Osteosynthesis in the Experiment
title_sort	bone regeneration in the application of a new device for osteosynthesis in the experiment
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/0fcbdb77548a40c1933f5d2f86f56346
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Bone Regeneration in the Application of a New Device for Osteosynthesis in the Experiment

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