Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.

Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.

<h4>Background</h4>The unique responsiveness of Vgamma9Vdelta2 T-cells, the major gammadelta subset of human peripheral blood, to non-peptidic prenyl pyrophosphate antigens constitutes the basis of current gammadelta T-cell-based cancer immunotherapy strategies. However, the molecular me...

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Autores principales: Daniel V Correia, Francisco d'Orey, Bruno A Cardoso, Telma Lança, Ana R Grosso, Ana deBarros, Leila R Martins, João T Barata, Bruno Silva-Santos
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/0fce580285754d5182dd4e971b07c240
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