Identifying the signature of prospective motor control in children with autism

Abstract Failure to develop prospective motor control has been proposed to be a core phenotypic marker of autism spectrum disorders (ASD). However, whether genuine differences in prospective motor control permit discriminating between ASD and non-ASD profiles over and above individual differences in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrea Cavallo, Luca Romeo, Caterina Ansuini, Francesca Battaglia, Lino Nobili, Massimiliano Pontil, Stefano Panzeri, Cristina Becchio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0fcec505eac24070b05aba9cd7a5c238
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0fcec505eac24070b05aba9cd7a5c238
record_format	dspace
spelling	oai:doaj.org-article:0fcec505eac24070b05aba9cd7a5c2382021-12-02T10:44:08ZIdentifying the signature of prospective motor control in children with autism10.1038/s41598-021-82374-22045-2322https://doaj.org/article/0fcec505eac24070b05aba9cd7a5c2382021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82374-2https://doaj.org/toc/2045-2322Abstract Failure to develop prospective motor control has been proposed to be a core phenotypic marker of autism spectrum disorders (ASD). However, whether genuine differences in prospective motor control permit discriminating between ASD and non-ASD profiles over and above individual differences in motor output remains unclear. Here, we combined high precision measures of hand movement kinematics and rigorous machine learning analyses to determine the true power of prospective movement data to differentiate children with autism and typically developing children. Our results show that while movement is unique to each individual, variations in the kinematic patterning of sequential grasping movements genuinely differentiate children with autism from typically developing children. These findings provide quantitative evidence for a prospective motor control impairment in autism and indicate the potential to draw inferences about autism on the basis of movement kinematics.Andrea CavalloLuca RomeoCaterina AnsuiniFrancesca BattagliaLino NobiliMassimiliano PontilStefano PanzeriCristina BecchioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea Cavallo Luca Romeo Caterina Ansuini Francesca Battaglia Lino Nobili Massimiliano Pontil Stefano Panzeri Cristina Becchio Identifying the signature of prospective motor control in children with autism
description	Abstract Failure to develop prospective motor control has been proposed to be a core phenotypic marker of autism spectrum disorders (ASD). However, whether genuine differences in prospective motor control permit discriminating between ASD and non-ASD profiles over and above individual differences in motor output remains unclear. Here, we combined high precision measures of hand movement kinematics and rigorous machine learning analyses to determine the true power of prospective movement data to differentiate children with autism and typically developing children. Our results show that while movement is unique to each individual, variations in the kinematic patterning of sequential grasping movements genuinely differentiate children with autism from typically developing children. These findings provide quantitative evidence for a prospective motor control impairment in autism and indicate the potential to draw inferences about autism on the basis of movement kinematics.
format	article
author	Andrea Cavallo Luca Romeo Caterina Ansuini Francesca Battaglia Lino Nobili Massimiliano Pontil Stefano Panzeri Cristina Becchio
author_facet	Andrea Cavallo Luca Romeo Caterina Ansuini Francesca Battaglia Lino Nobili Massimiliano Pontil Stefano Panzeri Cristina Becchio
author_sort	Andrea Cavallo
title	Identifying the signature of prospective motor control in children with autism
title_short	Identifying the signature of prospective motor control in children with autism
title_full	Identifying the signature of prospective motor control in children with autism
title_fullStr	Identifying the signature of prospective motor control in children with autism
title_full_unstemmed	Identifying the signature of prospective motor control in children with autism
title_sort	identifying the signature of prospective motor control in children with autism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0fcec505eac24070b05aba9cd7a5c238
work_keys_str_mv	AT andreacavallo identifyingthesignatureofprospectivemotorcontrolinchildrenwithautism AT lucaromeo identifyingthesignatureofprospectivemotorcontrolinchildrenwithautism AT caterinaansuini identifyingthesignatureofprospectivemotorcontrolinchildrenwithautism AT francescabattaglia identifyingthesignatureofprospectivemotorcontrolinchildrenwithautism AT linonobili identifyingthesignatureofprospectivemotorcontrolinchildrenwithautism AT massimilianopontil identifyingthesignatureofprospectivemotorcontrolinchildrenwithautism AT stefanopanzeri identifyingthesignatureofprospectivemotorcontrolinchildrenwithautism AT cristinabecchio identifyingthesignatureofprospectivemotorcontrolinchildrenwithautism
_version_	1718396808366915584

Identifying the signature of prospective motor control in children with autism

Ejemplares similares