The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease

Xiaoyan Hao, Qiang Zeng Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Qiang ZengHealth Management Institute, The Second Medical Cent...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hao X, Zeng Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	rs671 nash genotype foods Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0fd2079e2a754245908ef33f4af5ec31
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0fd2079e2a754245908ef33f4af5ec31
record_format	dspace
spelling	oai:doaj.org-article:0fd2079e2a754245908ef33f4af5ec312021-12-02T13:46:22ZThe Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease1178-7007https://doaj.org/article/0fd2079e2a754245908ef33f4af5ec312020-12-01T00:00:00Zhttps://www.dovepress.com/the-association-and-interaction-of-aldehyde-dehydrogenase-2-polymorphi-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xiaoyan Hao, Qiang Zeng Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Qiang ZengHealth Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaTel +86-10-68295751Fax +86-21-64085875Email hmi2020@126.comPurpose: This study investigated the association between the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, food group intake, and the probability of having non-alcoholic fatty liver disease (NAFLD) in a Chinese population.Patients and Methods: A total of 3506 adults were enrolled in this study, and all underwent physical examinations and genotyping of polymorphisms with polymerase chain reaction. Participants filled out a dietary questionnaire that was used to assess the frequency and quantity of food consumption.Results: We found that milk groups were associated with a lower probability of developing NAFLD. On the contrary, meat and salted and smoked foods were associated with a higher probability of NAFLD. However, the influences of salted and smoked foods and fresh fruit and vegetables on NAFLD were obviously different in the two genotype groups. Salted and smoked foods intake was a factor associated with a higher probability of having NAFLD or nonalcoholic steatohepatitis (NASH) in the A genotype group, but there was no effect in the G genotype group. Moreover, eating salted and smoked foods several times per week was associated with a higher probability of having NAFLD than seldom consuming them. Consumption of fresh fruit and vegetables was not a factor influencing the probability of having NAFLD in the A genotype group, and there was no effect in the G genotype group. Further analysis of the interaction indicated that the GA +AA genotype showed an interaction with fresh fruit and vegetables and salted and smoked foods. Moreover, it was not obvious that meat intake increased the probability of having NAFLD or NASH among different genotypes.Conclusion: Our results indicate that ALDH2 rs671 GA and AA genotypes are factors associated with increased probability of NAFLD among Chinese subjects. This could stimulate the development of novel approaches for preventing NAFLD.Keywords: rs671, NASH, genotype, foodsHao XZeng QDove Medical Pressarticlers671nashgenotypefoodsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 5049-5057 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rs671 nash genotype foods Specialties of internal medicine RC581-951
spellingShingle	rs671 nash genotype foods Specialties of internal medicine RC581-951 Hao X Zeng Q The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease
description	Xiaoyan Hao, Qiang Zeng Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Qiang ZengHealth Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaTel +86-10-68295751Fax +86-21-64085875Email hmi2020@126.comPurpose: This study investigated the association between the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, food group intake, and the probability of having non-alcoholic fatty liver disease (NAFLD) in a Chinese population.Patients and Methods: A total of 3506 adults were enrolled in this study, and all underwent physical examinations and genotyping of polymorphisms with polymerase chain reaction. Participants filled out a dietary questionnaire that was used to assess the frequency and quantity of food consumption.Results: We found that milk groups were associated with a lower probability of developing NAFLD. On the contrary, meat and salted and smoked foods were associated with a higher probability of NAFLD. However, the influences of salted and smoked foods and fresh fruit and vegetables on NAFLD were obviously different in the two genotype groups. Salted and smoked foods intake was a factor associated with a higher probability of having NAFLD or nonalcoholic steatohepatitis (NASH) in the A genotype group, but there was no effect in the G genotype group. Moreover, eating salted and smoked foods several times per week was associated with a higher probability of having NAFLD than seldom consuming them. Consumption of fresh fruit and vegetables was not a factor influencing the probability of having NAFLD in the A genotype group, and there was no effect in the G genotype group. Further analysis of the interaction indicated that the GA +AA genotype showed an interaction with fresh fruit and vegetables and salted and smoked foods. Moreover, it was not obvious that meat intake increased the probability of having NAFLD or NASH among different genotypes.Conclusion: Our results indicate that ALDH2 rs671 GA and AA genotypes are factors associated with increased probability of NAFLD among Chinese subjects. This could stimulate the development of novel approaches for preventing NAFLD.Keywords: rs671, NASH, genotype, foods
format	article
author	Hao X Zeng Q
author_facet	Hao X Zeng Q
author_sort	Hao X
title	The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease
title_short	The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease
title_full	The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease
title_fullStr	The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease
title_full_unstemmed	The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease
title_sort	association and interaction of aldehyde dehydrogenase 2 polymorphisms with food group intake and probability of having non-alcoholic fatty liver disease
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0fd2079e2a754245908ef33f4af5ec31
work_keys_str_mv	AT haox theassociationandinteractionofaldehydedehydrogenase2polymorphismswithfoodgroupintakeandprobabilityofhavingnonalcoholicfattyliverdisease AT zengq theassociationandinteractionofaldehydedehydrogenase2polymorphismswithfoodgroupintakeandprobabilityofhavingnonalcoholicfattyliverdisease AT haox associationandinteractionofaldehydedehydrogenase2polymorphismswithfoodgroupintakeandprobabilityofhavingnonalcoholicfattyliverdisease AT zengq associationandinteractionofaldehydedehydrogenase2polymorphismswithfoodgroupintakeandprobabilityofhavingnonalcoholicfattyliverdisease
_version_	1718392478897274880

The Association and Interaction of Aldehyde Dehydrogenase 2 Polymorphisms with Food Group Intake and Probability of Having Non-Alcoholic Fatty Liver Disease

Ejemplares similares