microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

The liver-specific microRNA-122 is an essential proviral host factor of Hepatitis C virus replication. Here the authors show that microRNA-122 functions as an RNA chaperone that guides the formation of a functional internal ribosome entry site by preventing energetically more favorable secondary str...

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Autores principales:	Philipp Schult, Hanna Roth, Rebecca L. Adams, Caroline Mas, Lionel Imbert, Christian Orlik, Alessia Ruggieri, Anna M. Pyle, Volker Lohmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0fd247a540674475b845c754d80d8b1f
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spelling	oai:doaj.org-article:0fd247a540674475b845c754d80d8b1f2021-12-02T14:41:06ZmicroRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site10.1038/s41467-018-05053-32041-1723https://doaj.org/article/0fd247a540674475b845c754d80d8b1f2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05053-3https://doaj.org/toc/2041-1723The liver-specific microRNA-122 is an essential proviral host factor of Hepatitis C virus replication. Here the authors show that microRNA-122 functions as an RNA chaperone that guides the formation of a functional internal ribosome entry site by preventing energetically more favorable secondary structures within the HCV RNA genome.Philipp SchultHanna RothRebecca L. AdamsCaroline MasLionel ImbertChristian OrlikAlessia RuggieriAnna M. PyleVolker LohmannNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philipp Schult Hanna Roth Rebecca L. Adams Caroline Mas Lionel Imbert Christian Orlik Alessia Ruggieri Anna M. Pyle Volker Lohmann microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site
description	The liver-specific microRNA-122 is an essential proviral host factor of Hepatitis C virus replication. Here the authors show that microRNA-122 functions as an RNA chaperone that guides the formation of a functional internal ribosome entry site by preventing energetically more favorable secondary structures within the HCV RNA genome.
format	article
author	Philipp Schult Hanna Roth Rebecca L. Adams Caroline Mas Lionel Imbert Christian Orlik Alessia Ruggieri Anna M. Pyle Volker Lohmann
author_facet	Philipp Schult Hanna Roth Rebecca L. Adams Caroline Mas Lionel Imbert Christian Orlik Alessia Ruggieri Anna M. Pyle Volker Lohmann
author_sort	Philipp Schult
title	microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site
title_short	microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site
title_full	microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site
title_fullStr	microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site
title_full_unstemmed	microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site
title_sort	microrna-122 amplifies hepatitis c virus translation by shaping the structure of the internal ribosomal entry site
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0fd247a540674475b845c754d80d8b1f
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microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

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