microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

The liver-specific microRNA-122 is an essential proviral host factor of Hepatitis C virus replication. Here the authors show that microRNA-122 functions as an RNA chaperone that guides the formation of a functional internal ribosome entry site by preventing energetically more favorable secondary str...

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Autores principales: Philipp Schult, Hanna Roth, Rebecca L. Adams, Caroline Mas, Lionel Imbert, Christian Orlik, Alessia Ruggieri, Anna M. Pyle, Volker Lohmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/0fd247a540674475b845c754d80d8b1f
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