Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

Abstract Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ct...

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Autores principales:	Samuel Terkper Ahuno, Anna-Lisa Doebley, Thomas U. Ahearn, Joel Yarney, Nicholas Titiloye, Nancy Hamel, Ernest Adjei, Joe-Nat Clegg-Lamptey, Lawrence Edusei, Baffour Awuah, Xiaoyu Song, Verna Vanderpuye, Mustapha Abubakar, Maire Duggan, Daniel G. Stover, Kofi Nyarko, John M. S. Bartlett, Francis Aitpillah, Daniel Ansong, Kevin L. Gardner, Felix Andy Boateng, Anne M. Bowcock, Carlos Caldas, William D. Foulkes, Seth Wiafe, Beatrice Wiafe-Addai, Montserrat Garcia-Closas, Alexander Kwarteng, Gavin Ha, Jonine D. Figueroa, Paz Polak, the Ghana Breast Health Study Team
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0fd72a4af12c4bc4bb78096b172d0185
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spelling	oai:doaj.org-article:0fd72a4af12c4bc4bb78096b172d01852021-12-02T17:23:38ZCirculating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa10.1038/s41698-021-00219-72397-768Xhttps://doaj.org/article/0fd72a4af12c4bc4bb78096b172d01852021-09-01T00:00:00Zhttps://doi.org/10.1038/s41698-021-00219-7https://doaj.org/toc/2397-768XAbstract Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.Samuel Terkper AhunoAnna-Lisa DoebleyThomas U. AhearnJoel YarneyNicholas TitiloyeNancy HamelErnest AdjeiJoe-Nat Clegg-LampteyLawrence EduseiBaffour AwuahXiaoyu SongVerna VanderpuyeMustapha AbubakarMaire DugganDaniel G. StoverKofi NyarkoJohn M. S. BartlettFrancis AitpillahDaniel AnsongKevin L. GardnerFelix Andy BoatengAnne M. BowcockCarlos CaldasWilliam D. FoulkesSeth WiafeBeatrice Wiafe-AddaiMontserrat Garcia-ClosasAlexander KwartengGavin HaJonine D. FigueroaPaz Polakthe Ghana Breast Health Study TeamNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Samuel Terkper Ahuno Anna-Lisa Doebley Thomas U. Ahearn Joel Yarney Nicholas Titiloye Nancy Hamel Ernest Adjei Joe-Nat Clegg-Lamptey Lawrence Edusei Baffour Awuah Xiaoyu Song Verna Vanderpuye Mustapha Abubakar Maire Duggan Daniel G. Stover Kofi Nyarko John M. S. Bartlett Francis Aitpillah Daniel Ansong Kevin L. Gardner Felix Andy Boateng Anne M. Bowcock Carlos Caldas William D. Foulkes Seth Wiafe Beatrice Wiafe-Addai Montserrat Garcia-Closas Alexander Kwarteng Gavin Ha Jonine D. Figueroa Paz Polak the Ghana Breast Health Study Team Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
description	Abstract Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.
format	article
author	Samuel Terkper Ahuno Anna-Lisa Doebley Thomas U. Ahearn Joel Yarney Nicholas Titiloye Nancy Hamel Ernest Adjei Joe-Nat Clegg-Lamptey Lawrence Edusei Baffour Awuah Xiaoyu Song Verna Vanderpuye Mustapha Abubakar Maire Duggan Daniel G. Stover Kofi Nyarko John M. S. Bartlett Francis Aitpillah Daniel Ansong Kevin L. Gardner Felix Andy Boateng Anne M. Bowcock Carlos Caldas William D. Foulkes Seth Wiafe Beatrice Wiafe-Addai Montserrat Garcia-Closas Alexander Kwarteng Gavin Ha Jonine D. Figueroa Paz Polak the Ghana Breast Health Study Team
author_facet	Samuel Terkper Ahuno Anna-Lisa Doebley Thomas U. Ahearn Joel Yarney Nicholas Titiloye Nancy Hamel Ernest Adjei Joe-Nat Clegg-Lamptey Lawrence Edusei Baffour Awuah Xiaoyu Song Verna Vanderpuye Mustapha Abubakar Maire Duggan Daniel G. Stover Kofi Nyarko John M. S. Bartlett Francis Aitpillah Daniel Ansong Kevin L. Gardner Felix Andy Boateng Anne M. Bowcock Carlos Caldas William D. Foulkes Seth Wiafe Beatrice Wiafe-Addai Montserrat Garcia-Closas Alexander Kwarteng Gavin Ha Jonine D. Figueroa Paz Polak the Ghana Breast Health Study Team
author_sort	Samuel Terkper Ahuno
title	Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
title_short	Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
title_full	Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
title_fullStr	Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
title_full_unstemmed	Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
title_sort	circulating tumor dna is readily detectable among ghanaian breast cancer patients supporting non-invasive cancer genomic studies in africa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0fd72a4af12c4bc4bb78096b172d0185
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Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

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