One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy

Alison E Hunter-Smith, Zenon Rayter Breast Surgery Unit, Bristol Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol, UK Abstract: Breast cancer is the most common cancer in women, worldwide, and 1,400 deaths per day are attributed to it. The success o...

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Autores principales:	Hunter-Smith AE, Rayter Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	breast cancer sentinel lymph node intra-operative assessment one-stop nucleic acid amplification. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0fdda85fc8bf443bbd70cdf95b91956c
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spelling	oai:doaj.org-article:0fdda85fc8bf443bbd70cdf95b91956c2021-12-02T06:01:06ZOne-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy1179-1314https://doaj.org/article/0fdda85fc8bf443bbd70cdf95b91956c2018-01-01T00:00:00Zhttps://www.dovepress.com/one-step-nucleic-acid-amplification-the-possible-value-in-assessing-se-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Alison E Hunter-Smith, Zenon Rayter Breast Surgery Unit, Bristol Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol, UK Abstract: Breast cancer is the most common cancer in women, worldwide, and 1,400 deaths per day are attributed to it. The success of national screening programs has seen breast cancers being diagnosed at an earlier stage. With conservative surgery to the breast demonstrating equivalent long-term outcomes, the last 10 years have seen a growing interest in the safety of less invasive management for the axilla in breast cancer patients. One-step nucleic acid amplification (OSNA) is a validated, reliable, and efficient tool in identifying micro- and macro-metastases intraoperatively. It is the most widely used intraoperative analysis tool within the United Kingdom, and is employed by over 320 units across Europe and Asia. Recent evidence from the AMAROS, IBCSG 23-01, and ACOSOG Z0011 trials has changed surgical practice in managing the axilla of patients with breast cancer. We propose a clinical algorithm demonstrating the role of OSNA as an intraoperative analysis tool in today’s management of breast cancer as well as prospects for the future use of OSNA. Keywords: breast cancer, sentinel lymph node, intraoperative assessment, one-stop nucleic acid amplification, mastectomyHunter-Smith AERayter ZDove Medical Pressarticlebreast cancersentinel lymph nodeintra-operative assessmentone-stop nucleic acid amplification.Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 10, Pp 13-21 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer sentinel lymph node intra-operative assessment one-stop nucleic acid amplification. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer sentinel lymph node intra-operative assessment one-stop nucleic acid amplification. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hunter-Smith AE Rayter Z One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy
description	Alison E Hunter-Smith, Zenon Rayter Breast Surgery Unit, Bristol Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol, UK Abstract: Breast cancer is the most common cancer in women, worldwide, and 1,400 deaths per day are attributed to it. The success of national screening programs has seen breast cancers being diagnosed at an earlier stage. With conservative surgery to the breast demonstrating equivalent long-term outcomes, the last 10 years have seen a growing interest in the safety of less invasive management for the axilla in breast cancer patients. One-step nucleic acid amplification (OSNA) is a validated, reliable, and efficient tool in identifying micro- and macro-metastases intraoperatively. It is the most widely used intraoperative analysis tool within the United Kingdom, and is employed by over 320 units across Europe and Asia. Recent evidence from the AMAROS, IBCSG 23-01, and ACOSOG Z0011 trials has changed surgical practice in managing the axilla of patients with breast cancer. We propose a clinical algorithm demonstrating the role of OSNA as an intraoperative analysis tool in today’s management of breast cancer as well as prospects for the future use of OSNA. Keywords: breast cancer, sentinel lymph node, intraoperative assessment, one-stop nucleic acid amplification, mastectomy
format	article
author	Hunter-Smith AE Rayter Z
author_facet	Hunter-Smith AE Rayter Z
author_sort	Hunter-Smith AE
title	One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy
title_short	One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy
title_full	One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy
title_fullStr	One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy
title_full_unstemmed	One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy
title_sort	one-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0fdda85fc8bf443bbd70cdf95b91956c
work_keys_str_mv	AT huntersmithae onestepnucleicacidamplificationthepossiblevalueinassessingsentinellymphnodemetastasisduringmastectomy AT rayterz onestepnucleicacidamplificationthepossiblevalueinassessingsentinellymphnodemetastasisduringmastectomy
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One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy

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