Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells

Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Therapeutic agents aimed at inhibiting a single molecular target have not been successful in cancer therapy, but rather they impart resistance. However, multi-target...

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Autor principal: Singh S
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Lenguaje:EN
Publicado: Dove Medical Press 2018
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Acceso en línea:https://doaj.org/article/0fddc80cf1e046f99472a75fe1b0011d
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spelling oai:doaj.org-article:0fddc80cf1e046f99472a75fe1b0011d2021-12-02T03:08:51ZLiposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells1178-2013https://doaj.org/article/0fddc80cf1e046f99472a75fe1b0011d2018-03-01T00:00:00Zhttps://www.dovepress.com/liposome-encapsulation-of-doxorubicin-and-celecoxib-in-combination-inh-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Therapeutic agents aimed at inhibiting a single molecular target have not been successful in cancer therapy, but rather they impart resistance. However, multi-target inhibitors have shown promising results in circumventing the development of resistance and inducing apoptosis in cancer cells/tissues. In this study, we encapsulated doxorubicin and celecoxib in a single liposome at a ratio of 1:10. These dual drug-encapsulated liposomes showed excellent anticancer activity compared to individually encapsulated liposomes. The expression of key proteins such as AKT and COX-2 was suppressed, which suggests that doxorubicin and celecoxib synergistically inhibit multiple key signaling pathways. Keywords: drug delivery, nanoliposomes, nanomedicines, cancer nanotechnologySingh SDove Medical PressarticleLiposomesDoxorubicinCelecoxibCancer NanotechnologyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 11-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Liposomes
Doxorubicin
Celecoxib
Cancer Nanotechnology
Medicine (General)
R5-920
spellingShingle Liposomes
Doxorubicin
Celecoxib
Cancer Nanotechnology
Medicine (General)
R5-920
Singh S
Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
description Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Therapeutic agents aimed at inhibiting a single molecular target have not been successful in cancer therapy, but rather they impart resistance. However, multi-target inhibitors have shown promising results in circumventing the development of resistance and inducing apoptosis in cancer cells/tissues. In this study, we encapsulated doxorubicin and celecoxib in a single liposome at a ratio of 1:10. These dual drug-encapsulated liposomes showed excellent anticancer activity compared to individually encapsulated liposomes. The expression of key proteins such as AKT and COX-2 was suppressed, which suggests that doxorubicin and celecoxib synergistically inhibit multiple key signaling pathways. Keywords: drug delivery, nanoliposomes, nanomedicines, cancer nanotechnology
format article
author Singh S
author_facet Singh S
author_sort Singh S
title Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
title_short Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
title_full Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
title_fullStr Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
title_full_unstemmed Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
title_sort liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/0fddc80cf1e046f99472a75fe1b0011d
work_keys_str_mv AT singhs liposomeencapsulationofdoxorubicinandcelecoxibincombinationinhibitsprogressionofhumanskincancercells
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