Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially dependent on p53/PARP1 activation and NAD+ depletion.

Guardado en:

Detalles Bibliográficos
Autores principales:	Giulia Fragola, Angela M. Mabb, Bonnie Taylor-Blake, Jesse K. Niehaus, William D. Chronister, Hanqian Mao, Jeremy M. Simon, Hong Yuan, Zibo Li, Michael J. McConnell, Mark J. Zylka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0fddde2332ce490c801aa1485380dfc3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0fddde2332ce490c801aa1485380dfc3
record_format	dspace
spelling	oai:doaj.org-article:0fddde2332ce490c801aa1485380dfc32021-12-02T14:41:00ZDeletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration10.1038/s41467-020-15794-92041-1723https://doaj.org/article/0fddde2332ce490c801aa1485380dfc32020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15794-9https://doaj.org/toc/2041-1723Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially dependent on p53/PARP1 activation and NAD+ depletion.Giulia FragolaAngela M. MabbBonnie Taylor-BlakeJesse K. NiehausWilliam D. ChronisterHanqian MaoJeremy M. SimonHong YuanZibo LiMichael J. McConnellMark J. ZylkaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulia Fragola Angela M. Mabb Bonnie Taylor-Blake Jesse K. Niehaus William D. Chronister Hanqian Mao Jeremy M. Simon Hong Yuan Zibo Li Michael J. McConnell Mark J. Zylka Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
description	Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially dependent on p53/PARP1 activation and NAD+ depletion.
format	article
author	Giulia Fragola Angela M. Mabb Bonnie Taylor-Blake Jesse K. Niehaus William D. Chronister Hanqian Mao Jeremy M. Simon Hong Yuan Zibo Li Michael J. McConnell Mark J. Zylka
author_facet	Giulia Fragola Angela M. Mabb Bonnie Taylor-Blake Jesse K. Niehaus William D. Chronister Hanqian Mao Jeremy M. Simon Hong Yuan Zibo Li Michael J. McConnell Mark J. Zylka
author_sort	Giulia Fragola
title	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_short	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_full	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_fullStr	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_full_unstemmed	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_sort	deletion of topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0fddde2332ce490c801aa1485380dfc3
work_keys_str_mv	AT giuliafragola deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT angelammabb deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT bonnietaylorblake deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT jessekniehaus deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT williamdchronister deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT hanqianmao deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT jeremymsimon deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT hongyuan deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT ziboli deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT michaeljmcconnell deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration AT markjzylka deletionoftopoisomerase1inexcitatoryneuronscausesgenomicinstabilityandearlyonsetneurodegeneration
_version_	1718390035972096000

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

Ejemplares similares