Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially dependent on p53/PARP1 activation and NAD+ depletion.

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Main Authors:	Giulia Fragola, Angela M. Mabb, Bonnie Taylor-Blake, Jesse K. Niehaus, William D. Chronister, Hanqian Mao, Jeremy M. Simon, Hong Yuan, Zibo Li, Michael J. McConnell, Mark J. Zylka
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/0fddde2332ce490c801aa1485380dfc3
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spelling	oai:doaj.org-article:0fddde2332ce490c801aa1485380dfc32021-12-02T14:41:00ZDeletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration10.1038/s41467-020-15794-92041-1723https://doaj.org/article/0fddde2332ce490c801aa1485380dfc32020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15794-9https://doaj.org/toc/2041-1723Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially dependent on p53/PARP1 activation and NAD+ depletion.Giulia FragolaAngela M. MabbBonnie Taylor-BlakeJesse K. NiehausWilliam D. ChronisterHanqian MaoJeremy M. SimonHong YuanZibo LiMichael J. McConnellMark J. ZylkaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulia Fragola Angela M. Mabb Bonnie Taylor-Blake Jesse K. Niehaus William D. Chronister Hanqian Mao Jeremy M. Simon Hong Yuan Zibo Li Michael J. McConnell Mark J. Zylka Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
description	Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially dependent on p53/PARP1 activation and NAD+ depletion.
format	article
author	Giulia Fragola Angela M. Mabb Bonnie Taylor-Blake Jesse K. Niehaus William D. Chronister Hanqian Mao Jeremy M. Simon Hong Yuan Zibo Li Michael J. McConnell Mark J. Zylka
author_facet	Giulia Fragola Angela M. Mabb Bonnie Taylor-Blake Jesse K. Niehaus William D. Chronister Hanqian Mao Jeremy M. Simon Hong Yuan Zibo Li Michael J. McConnell Mark J. Zylka
author_sort	Giulia Fragola
title	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_short	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_full	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_fullStr	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_full_unstemmed	Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
title_sort	deletion of topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0fddde2332ce490c801aa1485380dfc3
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Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

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