CHARACTERISTICS OF NEUROPEPTIDE-CYTOKINE IMMUNITY LINKS IN PATIENTS WITH COMBINED CARDIOVASCULAR PATHOLOGY, PROCEEDING WITH ANXIETY/DEPRESSION DISORDER

To date, pathogenetic events underlying coronary heart disease and hypertensive syndrome should be regarded as complex reactions of neuroimmune interactions characterized by activation of proinflammatory cytokines, opiate receptors and endogenous opioid peptides. These changes are mediated by high a...

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Autores principales:	A. V. Gertsev, Yu. N. Zakrevsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	ischemic disease hypertension anxiety depression β-endorphin cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0fded11cefd54771890741960e27db2f
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spelling	oai:doaj.org-article:0fded11cefd54771890741960e27db2f2021-11-18T08:03:47ZCHARACTERISTICS OF NEUROPEPTIDE-CYTOKINE IMMUNITY LINKS IN PATIENTS WITH COMBINED CARDIOVASCULAR PATHOLOGY, PROCEEDING WITH ANXIETY/DEPRESSION DISORDER1563-06252313-741X10.15789/1563-0625-2018-2-277-284https://doaj.org/article/0fded11cefd54771890741960e27db2f2018-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1480https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XTo date, pathogenetic events underlying coronary heart disease and hypertensive syndrome should be regarded as complex reactions of neuroimmune interactions characterized by activation of proinflammatory cytokines, opiate receptors and endogenous opioid peptides. These changes are mediated by high activity of basic regulatory systems that increase myocardial resistance to acute and chronic ischemic damage. However, there is lack of data concerning severity of these changes in the course of complicated coronary heart disease and hypertension, which occur in the background of anxiety-depressive disorders.The aim of present study was to assess regulatory disturbances at the level of neuropeptide-cytokine pool in the patients with polymorbid cardiovascular disease accomplished by anxiety and depressive conditions. Clinical examination of 85 patients (males) aged 35 to 45 years, with complicated cardiovascular disease (coronary heart disease combined with essential hypertension stage II) associated with anxiety and depressive disorders. To address these issues, we have formed a group of patients with anxiety and depressive disorders (group 1, n = 40), patients with coronary artery disease and stage II hypertension; group 2 (n = 20) included patients with coronary artery disease; group 3 (n = 25) included patients with hypertension stage II; group 4 (n = 30) represented controls (healthy person). In order to study dysfunction of regulatory neuropeptides at the level of cytokine-mediated immunity in these groups, we have studied diagnostic markers of the suprasegmentary autonomous nervous condition, and cytokine pool of immune system. Immune testing was used to determine β-endorphin, cytokines of pro-inflammatory (TNFα, IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) spectra in blood serum of patients.In the course of clinical and laboratory examination, the authors found that the patients with polymorbid cardiovascular pathology exhibit regulatory dysfunctions at the level of neuropeptide-cytokine links of immunity characterized by 1.5-2-fold decrease of β-endorphin levels, increase in pro-inflammatory cytokines (TNFα, IL-1β, IL-6) and decrease in anti-inflammatory (IL-4, IL-10) cytokines.A. V. GertsevYu. N. ZakrevskySPb RAACIarticleischemic diseasehypertensionanxietydepressionβ-endorphincytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 2, Pp 277-284 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	ischemic disease hypertension anxiety depression β-endorphin cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	ischemic disease hypertension anxiety depression β-endorphin cytokines Immunologic diseases. Allergy RC581-607 A. V. Gertsev Yu. N. Zakrevsky CHARACTERISTICS OF NEUROPEPTIDE-CYTOKINE IMMUNITY LINKS IN PATIENTS WITH COMBINED CARDIOVASCULAR PATHOLOGY, PROCEEDING WITH ANXIETY/DEPRESSION DISORDER
description	To date, pathogenetic events underlying coronary heart disease and hypertensive syndrome should be regarded as complex reactions of neuroimmune interactions characterized by activation of proinflammatory cytokines, opiate receptors and endogenous opioid peptides. These changes are mediated by high activity of basic regulatory systems that increase myocardial resistance to acute and chronic ischemic damage. However, there is lack of data concerning severity of these changes in the course of complicated coronary heart disease and hypertension, which occur in the background of anxiety-depressive disorders.The aim of present study was to assess regulatory disturbances at the level of neuropeptide-cytokine pool in the patients with polymorbid cardiovascular disease accomplished by anxiety and depressive conditions. Clinical examination of 85 patients (males) aged 35 to 45 years, with complicated cardiovascular disease (coronary heart disease combined with essential hypertension stage II) associated with anxiety and depressive disorders. To address these issues, we have formed a group of patients with anxiety and depressive disorders (group 1, n = 40), patients with coronary artery disease and stage II hypertension; group 2 (n = 20) included patients with coronary artery disease; group 3 (n = 25) included patients with hypertension stage II; group 4 (n = 30) represented controls (healthy person). In order to study dysfunction of regulatory neuropeptides at the level of cytokine-mediated immunity in these groups, we have studied diagnostic markers of the suprasegmentary autonomous nervous condition, and cytokine pool of immune system. Immune testing was used to determine β-endorphin, cytokines of pro-inflammatory (TNFα, IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) spectra in blood serum of patients.In the course of clinical and laboratory examination, the authors found that the patients with polymorbid cardiovascular pathology exhibit regulatory dysfunctions at the level of neuropeptide-cytokine links of immunity characterized by 1.5-2-fold decrease of β-endorphin levels, increase in pro-inflammatory cytokines (TNFα, IL-1β, IL-6) and decrease in anti-inflammatory (IL-4, IL-10) cytokines.
format	article
author	A. V. Gertsev Yu. N. Zakrevsky
author_facet	A. V. Gertsev Yu. N. Zakrevsky
author_sort	A. V. Gertsev
title	CHARACTERISTICS OF NEUROPEPTIDE-CYTOKINE IMMUNITY LINKS IN PATIENTS WITH COMBINED CARDIOVASCULAR PATHOLOGY, PROCEEDING WITH ANXIETY/DEPRESSION DISORDER
title_short	CHARACTERISTICS OF NEUROPEPTIDE-CYTOKINE IMMUNITY LINKS IN PATIENTS WITH COMBINED CARDIOVASCULAR PATHOLOGY, PROCEEDING WITH ANXIETY/DEPRESSION DISORDER
title_full	CHARACTERISTICS OF NEUROPEPTIDE-CYTOKINE IMMUNITY LINKS IN PATIENTS WITH COMBINED CARDIOVASCULAR PATHOLOGY, PROCEEDING WITH ANXIETY/DEPRESSION DISORDER
title_fullStr	CHARACTERISTICS OF NEUROPEPTIDE-CYTOKINE IMMUNITY LINKS IN PATIENTS WITH COMBINED CARDIOVASCULAR PATHOLOGY, PROCEEDING WITH ANXIETY/DEPRESSION DISORDER
title_full_unstemmed	CHARACTERISTICS OF NEUROPEPTIDE-CYTOKINE IMMUNITY LINKS IN PATIENTS WITH COMBINED CARDIOVASCULAR PATHOLOGY, PROCEEDING WITH ANXIETY/DEPRESSION DISORDER
title_sort	characteristics of neuropeptide-cytokine immunity links in patients with combined cardiovascular pathology, proceeding with anxiety/depression disorder
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/0fded11cefd54771890741960e27db2f
work_keys_str_mv	AT avgertsev characteristicsofneuropeptidecytokineimmunitylinksinpatientswithcombinedcardiovascularpathologyproceedingwithanxietydepressiondisorder AT yunzakrevsky characteristicsofneuropeptidecytokineimmunitylinksinpatientswithcombinedcardiovascularpathologyproceedingwithanxietydepressiondisorder
_version_	1718422333622845440

CHARACTERISTICS OF NEUROPEPTIDE-CYTOKINE IMMUNITY LINKS IN PATIENTS WITH COMBINED CARDIOVASCULAR PATHOLOGY, PROCEEDING WITH ANXIETY/DEPRESSION DISORDER

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