PI3Kγ promotes obesity-associated hepatocellular carcinoma by regulating metabolism and inflammation

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PI3Kγ promotes obesity-associated hepatocellular carcinoma by regulating metabolism and inflammation

Background & Aims: Phosphatidylinositides-3 kinases (PI3Ks) are promising drug targets for cancer therapy, but blockage of PI3K-AKT signalling causes hyperglycaemia, hyperinsulinaemia, and liver damage in patients, and hepatocellular carcinoma (HCC) in mice. There are 4 PI3Ks: PI3Kα, PI3Kβ,...

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Autores principales:	Barbara Becattini, Ludovic Breasson, Claudia Sardi, Fabio Zani, Giovanni Solinas
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	NAFLD NASH Insulin AKT mTOR Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/0fe2adb7ba684bfba3441a0071b78ab9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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