Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD

Abstract Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics compared to those without COPD. In this stud...

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Autores principales:	Dakai Xiao, Fuqiang Li, Hui Pan, Han Liang, Kui Wu, Jianxing He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0fe4f78176d74b3ea40434b0d81dc6fa
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spelling	oai:doaj.org-article:0fe4f78176d74b3ea40434b0d81dc6fa2021-12-02T16:08:08ZIntegrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD10.1038/s41598-017-02405-92045-2322https://doaj.org/article/0fe4f78176d74b3ea40434b0d81dc6fa2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02405-9https://doaj.org/toc/2045-2322Abstract Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics compared to those without COPD. In this study, we retrospectively analyzed genomic sequencing data from 272 patients with lung adenocarcinoma (LUAD) and compared the genetic alterations in LUAD patients with and without COPD. Integrative analysis of whole-genome and exome sequencing data revealed that COPD and non-COPD groups showed high concordance in mutational burden and spectra. Notably, we also found that EGFR mutations were more prevalent in LUAD patients without COPD, whereas mutated LRP1B was more frequently observed in LUAD patients with COPD. In addition, multi-variable analysis with logistic regression demonstrated that mutation of LRP1B was a predictive marker for the presence of COPD in the patients with LUAD. Our analysis demonstrated for the first time the high concordance in genomic alterations between the tumors from LUAD patients with and without COPD. We also identified higher prevalence of LRP1B among the LUAD patients with COPD, which might help understand the underlying mechanisms which link COPD and lung cancer.Dakai XiaoFuqiang LiHui PanHan LiangKui WuJianxing HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dakai Xiao Fuqiang Li Hui Pan Han Liang Kui Wu Jianxing He Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD
description	Abstract Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics compared to those without COPD. In this study, we retrospectively analyzed genomic sequencing data from 272 patients with lung adenocarcinoma (LUAD) and compared the genetic alterations in LUAD patients with and without COPD. Integrative analysis of whole-genome and exome sequencing data revealed that COPD and non-COPD groups showed high concordance in mutational burden and spectra. Notably, we also found that EGFR mutations were more prevalent in LUAD patients without COPD, whereas mutated LRP1B was more frequently observed in LUAD patients with COPD. In addition, multi-variable analysis with logistic regression demonstrated that mutation of LRP1B was a predictive marker for the presence of COPD in the patients with LUAD. Our analysis demonstrated for the first time the high concordance in genomic alterations between the tumors from LUAD patients with and without COPD. We also identified higher prevalence of LRP1B among the LUAD patients with COPD, which might help understand the underlying mechanisms which link COPD and lung cancer.
format	article
author	Dakai Xiao Fuqiang Li Hui Pan Han Liang Kui Wu Jianxing He
author_facet	Dakai Xiao Fuqiang Li Hui Pan Han Liang Kui Wu Jianxing He
author_sort	Dakai Xiao
title	Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD
title_short	Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD
title_full	Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD
title_fullStr	Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD
title_full_unstemmed	Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD
title_sort	integrative analysis of genomic sequencing data reveals higher prevalence of lrp1b mutations in lung adenocarcinoma patients with copd
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0fe4f78176d74b3ea40434b0d81dc6fa
work_keys_str_mv	AT dakaixiao integrativeanalysisofgenomicsequencingdatarevealshigherprevalenceoflrp1bmutationsinlungadenocarcinomapatientswithcopd AT fuqiangli integrativeanalysisofgenomicsequencingdatarevealshigherprevalenceoflrp1bmutationsinlungadenocarcinomapatientswithcopd AT huipan integrativeanalysisofgenomicsequencingdatarevealshigherprevalenceoflrp1bmutationsinlungadenocarcinomapatientswithcopd AT hanliang integrativeanalysisofgenomicsequencingdatarevealshigherprevalenceoflrp1bmutationsinlungadenocarcinomapatientswithcopd AT kuiwu integrativeanalysisofgenomicsequencingdatarevealshigherprevalenceoflrp1bmutationsinlungadenocarcinomapatientswithcopd AT jianxinghe integrativeanalysisofgenomicsequencingdatarevealshigherprevalenceoflrp1bmutationsinlungadenocarcinomapatientswithcopd
_version_	1718384576405962752

Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD

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