Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form

Five various chemometric methods were established for the simultaneous determination of azilsartan medoxomil (AZM) and chlorthalidone in the presence of azilsartan which is the core impurity of AZM. The full spectrum-based chemometric techniques, namely partial least squares (PLS), principal compone...

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Autores principales:	Darwish Hany W., Al Majed Abdulrahman A., Al-Suwaidan Ibrahim A., Darwish Ibrahim A., Bakheit Ahmed H., Al-Shehri Hassan H.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	chlorthalidone azilsartan medoxomil azilsartan ga ann Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0fe79ff55aea41b0a4be98c139d01224
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spelling	oai:doaj.org-article:0fe79ff55aea41b0a4be98c139d012242021-12-05T14:10:43ZFull spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form2391-542010.1515/chem-2021-0022https://doaj.org/article/0fe79ff55aea41b0a4be98c139d012242021-03-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0022https://doaj.org/toc/2391-5420Five various chemometric methods were established for the simultaneous determination of azilsartan medoxomil (AZM) and chlorthalidone in the presence of azilsartan which is the core impurity of AZM. The full spectrum-based chemometric techniques, namely partial least squares (PLS), principal component regression, and artificial neural networks (ANN), were among the applied methods. Besides, the ANN and PLS were the other two methods that were extended by genetic algorithm procedure (GA-PLS and GA-ANN) as a wavelength selection procedure. The models were developed by applying a multilevel multifactor experimental design. The predictive power of the suggested models was evaluated through a validation set containing nine mixtures with different ratios of the three analytes. For the analysis of Edarbyclor® tablets, all the proposed procedures were applied and the best results were achieved in the case of ANN, GA-ANN, and GA-PLS methods. The findings of the three methods were revealed as the quantitative tool for the analysis of the three components without any intrusion from the co-formulated excipient and without prior separation procedures. Moreover, the GA impact on strengthening the predictive power of ANN- and PLS-based models was also highlighted.Darwish Hany W.Al Majed Abdulrahman A.Al-Suwaidan Ibrahim A.Darwish Ibrahim A.Bakheit Ahmed H.Al-Shehri Hassan H.De Gruyterarticlechlorthalidoneazilsartan medoxomilazilsartangaannChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 205-213 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chlorthalidone azilsartan medoxomil azilsartan ga ann Chemistry QD1-999
spellingShingle	chlorthalidone azilsartan medoxomil azilsartan ga ann Chemistry QD1-999 Darwish Hany W. Al Majed Abdulrahman A. Al-Suwaidan Ibrahim A. Darwish Ibrahim A. Bakheit Ahmed H. Al-Shehri Hassan H. Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form
description	Five various chemometric methods were established for the simultaneous determination of azilsartan medoxomil (AZM) and chlorthalidone in the presence of azilsartan which is the core impurity of AZM. The full spectrum-based chemometric techniques, namely partial least squares (PLS), principal component regression, and artificial neural networks (ANN), were among the applied methods. Besides, the ANN and PLS were the other two methods that were extended by genetic algorithm procedure (GA-PLS and GA-ANN) as a wavelength selection procedure. The models were developed by applying a multilevel multifactor experimental design. The predictive power of the suggested models was evaluated through a validation set containing nine mixtures with different ratios of the three analytes. For the analysis of Edarbyclor® tablets, all the proposed procedures were applied and the best results were achieved in the case of ANN, GA-ANN, and GA-PLS methods. The findings of the three methods were revealed as the quantitative tool for the analysis of the three components without any intrusion from the co-formulated excipient and without prior separation procedures. Moreover, the GA impact on strengthening the predictive power of ANN- and PLS-based models was also highlighted.
format	article
author	Darwish Hany W. Al Majed Abdulrahman A. Al-Suwaidan Ibrahim A. Darwish Ibrahim A. Bakheit Ahmed H. Al-Shehri Hassan H.
author_facet	Darwish Hany W. Al Majed Abdulrahman A. Al-Suwaidan Ibrahim A. Darwish Ibrahim A. Bakheit Ahmed H. Al-Shehri Hassan H.
author_sort	Darwish Hany W.
title	Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form
title_short	Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form
title_full	Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form
title_fullStr	Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form
title_full_unstemmed	Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form
title_sort	full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: development, validation, and application on commercial dosage form
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/0fe79ff55aea41b0a4be98c139d01224
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Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form

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