Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy

Bacterial biofilms rely on shared extracellular polymeric substances (EPS) and are often highly tolerant to antibiotics. Here, the authors show in in vitro experiments that Salmonella does not evolve resistance to EPS inhibition because such strains are outcompeted by a susceptible strain under inhi...

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Autores principales: Lise Dieltjens, Kenny Appermans, Maries Lissens, Bram Lories, Wook Kim, Erik V. Van der Eycken, Kevin R. Foster, Hans P. Steenackers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0fe92426ee98474f992afb748d21b64e
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spelling oai:doaj.org-article:0fe92426ee98474f992afb748d21b64e2021-12-02T15:37:17ZInhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy10.1038/s41467-019-13660-x2041-1723https://doaj.org/article/0fe92426ee98474f992afb748d21b64e2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13660-xhttps://doaj.org/toc/2041-1723Bacterial biofilms rely on shared extracellular polymeric substances (EPS) and are often highly tolerant to antibiotics. Here, the authors show in in vitro experiments that Salmonella does not evolve resistance to EPS inhibition because such strains are outcompeted by a susceptible strain under inhibitor treatment.Lise DieltjensKenny AppermansMaries LissensBram LoriesWook KimErik V. Van der EyckenKevin R. FosterHans P. SteenackersNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lise Dieltjens
Kenny Appermans
Maries Lissens
Bram Lories
Wook Kim
Erik V. Van der Eycken
Kevin R. Foster
Hans P. Steenackers
Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy
description Bacterial biofilms rely on shared extracellular polymeric substances (EPS) and are often highly tolerant to antibiotics. Here, the authors show in in vitro experiments that Salmonella does not evolve resistance to EPS inhibition because such strains are outcompeted by a susceptible strain under inhibitor treatment.
format article
author Lise Dieltjens
Kenny Appermans
Maries Lissens
Bram Lories
Wook Kim
Erik V. Van der Eycken
Kevin R. Foster
Hans P. Steenackers
author_facet Lise Dieltjens
Kenny Appermans
Maries Lissens
Bram Lories
Wook Kim
Erik V. Van der Eycken
Kevin R. Foster
Hans P. Steenackers
author_sort Lise Dieltjens
title Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy
title_short Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy
title_full Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy
title_fullStr Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy
title_full_unstemmed Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy
title_sort inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/0fe92426ee98474f992afb748d21b64e
work_keys_str_mv AT lisedieltjens inhibitingbacterialcooperationisanevolutionarilyrobustantibiofilmstrategy
AT kennyappermans inhibitingbacterialcooperationisanevolutionarilyrobustantibiofilmstrategy
AT marieslissens inhibitingbacterialcooperationisanevolutionarilyrobustantibiofilmstrategy
AT bramlories inhibitingbacterialcooperationisanevolutionarilyrobustantibiofilmstrategy
AT wookkim inhibitingbacterialcooperationisanevolutionarilyrobustantibiofilmstrategy
AT erikvvandereycken inhibitingbacterialcooperationisanevolutionarilyrobustantibiofilmstrategy
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AT hanspsteenackers inhibitingbacterialcooperationisanevolutionarilyrobustantibiofilmstrategy
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