Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

Reprogramming of somatic cells is a stepwise process where cells must overcome several barriers before reaching the pluripotent state. Here the authors show that mitochondrial fission in response to ERK1/2 signalling is an important early step during reprogramming to pluripotency.

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Autores principales:	Javier Prieto, Marian León, Xavier Ponsoda, Ramón Sendra, Roque Bort, Raquel Ferrer-Lorente, Angel Raya, Carlos López-García, Josema Torres
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0fea78d669cb46258b35840c49ca6d36
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spelling	oai:doaj.org-article:0fea78d669cb46258b35840c49ca6d362021-12-02T16:49:27ZEarly ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming10.1038/ncomms111242041-1723https://doaj.org/article/0fea78d669cb46258b35840c49ca6d362016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11124https://doaj.org/toc/2041-1723Reprogramming of somatic cells is a stepwise process where cells must overcome several barriers before reaching the pluripotent state. Here the authors show that mitochondrial fission in response to ERK1/2 signalling is an important early step during reprogramming to pluripotency.Javier PrietoMarian LeónXavier PonsodaRamón SendraRoque BortRaquel Ferrer-LorenteAngel RayaCarlos López-GarcíaJosema TorresNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Javier Prieto Marian León Xavier Ponsoda Ramón Sendra Roque Bort Raquel Ferrer-Lorente Angel Raya Carlos López-García Josema Torres Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
description	Reprogramming of somatic cells is a stepwise process where cells must overcome several barriers before reaching the pluripotent state. Here the authors show that mitochondrial fission in response to ERK1/2 signalling is an important early step during reprogramming to pluripotency.
format	article
author	Javier Prieto Marian León Xavier Ponsoda Ramón Sendra Roque Bort Raquel Ferrer-Lorente Angel Raya Carlos López-García Josema Torres
author_facet	Javier Prieto Marian León Xavier Ponsoda Ramón Sendra Roque Bort Raquel Ferrer-Lorente Angel Raya Carlos López-García Josema Torres
author_sort	Javier Prieto
title	Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
title_short	Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
title_full	Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
title_fullStr	Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
title_full_unstemmed	Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
title_sort	early erk1/2 activation promotes drp1-dependent mitochondrial fission necessary for cell reprogramming
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0fea78d669cb46258b35840c49ca6d36
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Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

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