Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

Reprogramming of somatic cells is a stepwise process where cells must overcome several barriers before reaching the pluripotent state. Here the authors show that mitochondrial fission in response to ERK1/2 signalling is an important early step during reprogramming to pluripotency.

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Detalles Bibliográficos
Autores principales: Javier Prieto, Marian León, Xavier Ponsoda, Ramón Sendra, Roque Bort, Raquel Ferrer-Lorente, Angel Raya, Carlos López-García, Josema Torres
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/0fea78d669cb46258b35840c49ca6d36
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