Vesicular glutamate release from central axons contributes to myelin damage

Neuronal activity can lead to vesicular release of glutamate. Here the authors demonstrate that vesicular release of glutamate occurs in axons during ischemic conditions, and that an allosteric modulator of GluN2C/D is protective in models of ischemic injury.

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Autores principales:	Sean Doyle, Daniel Bloch Hansen, Jasmine Vella, Peter Bond, Glenn Harper, Christian Zammit, Mario Valentino, Robert Fern
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0fed273f84fb4c6cb8cc3f40c6cd9547
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spelling	oai:doaj.org-article:0fed273f84fb4c6cb8cc3f40c6cd95472021-12-02T16:50:06ZVesicular glutamate release from central axons contributes to myelin damage10.1038/s41467-018-03427-12041-1723https://doaj.org/article/0fed273f84fb4c6cb8cc3f40c6cd95472018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03427-1https://doaj.org/toc/2041-1723Neuronal activity can lead to vesicular release of glutamate. Here the authors demonstrate that vesicular release of glutamate occurs in axons during ischemic conditions, and that an allosteric modulator of GluN2C/D is protective in models of ischemic injury.Sean DoyleDaniel Bloch HansenJasmine VellaPeter BondGlenn HarperChristian ZammitMario ValentinoRobert FernNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sean Doyle Daniel Bloch Hansen Jasmine Vella Peter Bond Glenn Harper Christian Zammit Mario Valentino Robert Fern Vesicular glutamate release from central axons contributes to myelin damage
description	Neuronal activity can lead to vesicular release of glutamate. Here the authors demonstrate that vesicular release of glutamate occurs in axons during ischemic conditions, and that an allosteric modulator of GluN2C/D is protective in models of ischemic injury.
format	article
author	Sean Doyle Daniel Bloch Hansen Jasmine Vella Peter Bond Glenn Harper Christian Zammit Mario Valentino Robert Fern
author_facet	Sean Doyle Daniel Bloch Hansen Jasmine Vella Peter Bond Glenn Harper Christian Zammit Mario Valentino Robert Fern
author_sort	Sean Doyle
title	Vesicular glutamate release from central axons contributes to myelin damage
title_short	Vesicular glutamate release from central axons contributes to myelin damage
title_full	Vesicular glutamate release from central axons contributes to myelin damage
title_fullStr	Vesicular glutamate release from central axons contributes to myelin damage
title_full_unstemmed	Vesicular glutamate release from central axons contributes to myelin damage
title_sort	vesicular glutamate release from central axons contributes to myelin damage
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0fed273f84fb4c6cb8cc3f40c6cd9547
work_keys_str_mv	AT seandoyle vesicularglutamatereleasefromcentralaxonscontributestomyelindamage AT danielblochhansen vesicularglutamatereleasefromcentralaxonscontributestomyelindamage AT jasminevella vesicularglutamatereleasefromcentralaxonscontributestomyelindamage AT peterbond vesicularglutamatereleasefromcentralaxonscontributestomyelindamage AT glennharper vesicularglutamatereleasefromcentralaxonscontributestomyelindamage AT christianzammit vesicularglutamatereleasefromcentralaxonscontributestomyelindamage AT mariovalentino vesicularglutamatereleasefromcentralaxonscontributestomyelindamage AT robertfern vesicularglutamatereleasefromcentralaxonscontributestomyelindamage
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Vesicular glutamate release from central axons contributes to myelin damage

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