Functional interaction between Wnt and Bmp signaling in periosteal bone growth

Abstract Wnt and Bmp proteins are well known to regulate bone development and homeostasis. Although both signals are extensively studied, their potential interaction in vivo is less well understood. Previous studies have shown that deletion of Bmpr1a, a type I receptor for Bmp signaling, results in...

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Autores principales:	Deye Song, Guangxu He, Yu Shi, Jiangdong Ni, Fanxin Long
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0fee0d83946741c5b1c922a31a5da2b4
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spelling	oai:doaj.org-article:0fee0d83946741c5b1c922a31a5da2b42021-12-02T15:49:45ZFunctional interaction between Wnt and Bmp signaling in periosteal bone growth10.1038/s41598-021-90324-12045-2322https://doaj.org/article/0fee0d83946741c5b1c922a31a5da2b42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90324-1https://doaj.org/toc/2045-2322Abstract Wnt and Bmp proteins are well known to regulate bone development and homeostasis. Although both signals are extensively studied, their potential interaction in vivo is less well understood. Previous studies have shown that deletion of Bmpr1a, a type I receptor for Bmp signaling, results in excessive trabecular bone formation while diminishing periosteal bone growth. Moreover, forced-expression of the Wnt antagonist Sost suppresses the overgrowth of trabecular bone caused by Bmpr1a deletion, thus implicating hyperactive Wnt signaling in the excessive trabecular bone formation. However, it remains uncertain whether Wnt and Bmp signaling interacts in regulating the periosteal bone growth. Here we show that multiple Wnt genes are markedly suppressed in the cortical bone without Bmpr1a. Importantly, overexpression of Wnt7b fully rescues periosteal bone growth in the Bmpr1a-deficient mice. Thus, pharmacological activation of Wnt signaling can restore normal bone size without intact Bmp signaling.Deye SongGuangxu HeYu ShiJiangdong NiFanxin LongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Deye Song Guangxu He Yu Shi Jiangdong Ni Fanxin Long Functional interaction between Wnt and Bmp signaling in periosteal bone growth
description	Abstract Wnt and Bmp proteins are well known to regulate bone development and homeostasis. Although both signals are extensively studied, their potential interaction in vivo is less well understood. Previous studies have shown that deletion of Bmpr1a, a type I receptor for Bmp signaling, results in excessive trabecular bone formation while diminishing periosteal bone growth. Moreover, forced-expression of the Wnt antagonist Sost suppresses the overgrowth of trabecular bone caused by Bmpr1a deletion, thus implicating hyperactive Wnt signaling in the excessive trabecular bone formation. However, it remains uncertain whether Wnt and Bmp signaling interacts in regulating the periosteal bone growth. Here we show that multiple Wnt genes are markedly suppressed in the cortical bone without Bmpr1a. Importantly, overexpression of Wnt7b fully rescues periosteal bone growth in the Bmpr1a-deficient mice. Thus, pharmacological activation of Wnt signaling can restore normal bone size without intact Bmp signaling.
format	article
author	Deye Song Guangxu He Yu Shi Jiangdong Ni Fanxin Long
author_facet	Deye Song Guangxu He Yu Shi Jiangdong Ni Fanxin Long
author_sort	Deye Song
title	Functional interaction between Wnt and Bmp signaling in periosteal bone growth
title_short	Functional interaction between Wnt and Bmp signaling in periosteal bone growth
title_full	Functional interaction between Wnt and Bmp signaling in periosteal bone growth
title_fullStr	Functional interaction between Wnt and Bmp signaling in periosteal bone growth
title_full_unstemmed	Functional interaction between Wnt and Bmp signaling in periosteal bone growth
title_sort	functional interaction between wnt and bmp signaling in periosteal bone growth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0fee0d83946741c5b1c922a31a5da2b4
work_keys_str_mv	AT deyesong functionalinteractionbetweenwntandbmpsignalinginperiostealbonegrowth AT guangxuhe functionalinteractionbetweenwntandbmpsignalinginperiostealbonegrowth AT yushi functionalinteractionbetweenwntandbmpsignalinginperiostealbonegrowth AT jiangdongni functionalinteractionbetweenwntandbmpsignalinginperiostealbonegrowth AT fanxinlong functionalinteractionbetweenwntandbmpsignalinginperiostealbonegrowth
_version_	1718385673925296128

Functional interaction between Wnt and Bmp signaling in periosteal bone growth

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