Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.

Salmonella enterica serovar Typhimurium (Salmonella) is one of the most significant food-borne pathogens affecting both humans and agriculture. We have determined that Salmonella encodes an uptake and utilization pathway specific for a novel nutrient, fructose-asparagine (F-Asn), which is essential...

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Autores principales:	Mohamed M Ali, David L Newsom, Juan F González, Anice Sabag-Daigle, Christopher Stahl, Brandi Steidley, Judith Dubena, Jessica L Dyszel, Jenee N Smith, Yakhya Dieye, Razvan Arsenescu, Prosper N Boyaka, Steven Krakowka, Tony Romeo, Edward J Behrman, Peter White, Brian M M Ahmer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0fef27573840418b8ba46fa51b636d50
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spelling	oai:doaj.org-article:0fef27573840418b8ba46fa51b636d502021-11-11T06:06:08ZFructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.1553-73661553-737410.1371/journal.ppat.1004209https://doaj.org/article/0fef27573840418b8ba46fa51b636d502014-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24967579/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Salmonella enterica serovar Typhimurium (Salmonella) is one of the most significant food-borne pathogens affecting both humans and agriculture. We have determined that Salmonella encodes an uptake and utilization pathway specific for a novel nutrient, fructose-asparagine (F-Asn), which is essential for Salmonella fitness in the inflamed intestine (modeled using germ-free, streptomycin-treated, ex-germ-free with human microbiota, and IL10-/- mice). The locus encoding F-Asn utilization, fra, provides an advantage only if Salmonella can initiate inflammation and use tetrathionate as a terminal electron acceptor for anaerobic respiration (the fra phenotype is lost in Salmonella SPI1- SPI2- or ttrA mutants, respectively). The severe fitness defect of a Salmonella fra mutant suggests that F-Asn is the primary nutrient utilized by Salmonella in the inflamed intestine and that this system provides a valuable target for novel therapies.Mohamed M AliDavid L NewsomJuan F GonzálezAnice Sabag-DaigleChristopher StahlBrandi SteidleyJudith DubenaJessica L DyszelJenee N SmithYakhya DieyeRazvan ArsenescuProsper N BoyakaSteven KrakowkaTony RomeoEdward J BehrmanPeter WhiteBrian M M AhmerPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 10, Iss 6, p e1004209 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Mohamed M Ali David L Newsom Juan F González Anice Sabag-Daigle Christopher Stahl Brandi Steidley Judith Dubena Jessica L Dyszel Jenee N Smith Yakhya Dieye Razvan Arsenescu Prosper N Boyaka Steven Krakowka Tony Romeo Edward J Behrman Peter White Brian M M Ahmer Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.
description	Salmonella enterica serovar Typhimurium (Salmonella) is one of the most significant food-borne pathogens affecting both humans and agriculture. We have determined that Salmonella encodes an uptake and utilization pathway specific for a novel nutrient, fructose-asparagine (F-Asn), which is essential for Salmonella fitness in the inflamed intestine (modeled using germ-free, streptomycin-treated, ex-germ-free with human microbiota, and IL10-/- mice). The locus encoding F-Asn utilization, fra, provides an advantage only if Salmonella can initiate inflammation and use tetrathionate as a terminal electron acceptor for anaerobic respiration (the fra phenotype is lost in Salmonella SPI1- SPI2- or ttrA mutants, respectively). The severe fitness defect of a Salmonella fra mutant suggests that F-Asn is the primary nutrient utilized by Salmonella in the inflamed intestine and that this system provides a valuable target for novel therapies.
format	article
author	Mohamed M Ali David L Newsom Juan F González Anice Sabag-Daigle Christopher Stahl Brandi Steidley Judith Dubena Jessica L Dyszel Jenee N Smith Yakhya Dieye Razvan Arsenescu Prosper N Boyaka Steven Krakowka Tony Romeo Edward J Behrman Peter White Brian M M Ahmer
author_facet	Mohamed M Ali David L Newsom Juan F González Anice Sabag-Daigle Christopher Stahl Brandi Steidley Judith Dubena Jessica L Dyszel Jenee N Smith Yakhya Dieye Razvan Arsenescu Prosper N Boyaka Steven Krakowka Tony Romeo Edward J Behrman Peter White Brian M M Ahmer
author_sort	Mohamed M Ali
title	Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.
title_short	Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.
title_full	Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.
title_fullStr	Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.
title_full_unstemmed	Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.
title_sort	fructose-asparagine is a primary nutrient during growth of salmonella in the inflamed intestine.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0fef27573840418b8ba46fa51b636d50
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Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine.

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