Genetically engineered nanocarriers for drug delivery

Pu Shi, Joshua A Gustafson, J Andrew MacKayDepartment of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USAAbstract: Cytotoxicity, low water solubility, rapid clearance from circulation, and off-target side-effects are common drawbacks of conventional...

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Autores principales:	Shi P, Gustafson JA, MacKay JA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0fef916374b941caa6d78bd54248732c
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spelling	oai:doaj.org-article:0fef916374b941caa6d78bd54248732c2021-12-02T07:28:32ZGenetically engineered nanocarriers for drug delivery1178-2013https://doaj.org/article/0fef916374b941caa6d78bd54248732c2014-03-01T00:00:00Zhttp://www.dovepress.com/genetically-engineered-nanocarriers-for-drug-delivery-a16250https://doaj.org/toc/1178-2013 Pu Shi, Joshua A Gustafson, J Andrew MacKayDepartment of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USAAbstract: Cytotoxicity, low water solubility, rapid clearance from circulation, and off-target side-effects are common drawbacks of conventional small-molecule drugs. To overcome these shortcomings, many multifunctional nanocarriers have been proposed to enhance drug delivery. In concept, multifunctional nanoparticles might carry multiple agents, control release rate, biodegrade, and utilize target-mediated drug delivery; however, the design of these particles presents many challenges at the stage of pharmaceutical development. An emerging solution to improve control over these particles is to turn to genetic engineering. Genetically engineered nanocarriers are precisely controlled in size and structure and can provide specific control over sites for chemical attachment of drugs. Genetically engineered drug carriers that assemble nanostructures including nanoparticles and nanofibers can be polymeric or non-polymeric. This review summarizes the recent development of applications in drug and gene delivery utilizing nanostructures of polymeric genetically engineered drug carriers such as elastin-like polypeptides, silk-like polypeptides, and silk-elastin-like protein polymers, and non-polymeric genetically engineered drug carriers such as vault proteins and viral proteins.Keywords: polymeric drug carrier, non-polymeric drug carrier, gene delivery, GE drug carriersShi PGustafson JAMacKay JADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1617-1626 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Shi P Gustafson JA MacKay JA Genetically engineered nanocarriers for drug delivery
description	Pu Shi, Joshua A Gustafson, J Andrew MacKayDepartment of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USAAbstract: Cytotoxicity, low water solubility, rapid clearance from circulation, and off-target side-effects are common drawbacks of conventional small-molecule drugs. To overcome these shortcomings, many multifunctional nanocarriers have been proposed to enhance drug delivery. In concept, multifunctional nanoparticles might carry multiple agents, control release rate, biodegrade, and utilize target-mediated drug delivery; however, the design of these particles presents many challenges at the stage of pharmaceutical development. An emerging solution to improve control over these particles is to turn to genetic engineering. Genetically engineered nanocarriers are precisely controlled in size and structure and can provide specific control over sites for chemical attachment of drugs. Genetically engineered drug carriers that assemble nanostructures including nanoparticles and nanofibers can be polymeric or non-polymeric. This review summarizes the recent development of applications in drug and gene delivery utilizing nanostructures of polymeric genetically engineered drug carriers such as elastin-like polypeptides, silk-like polypeptides, and silk-elastin-like protein polymers, and non-polymeric genetically engineered drug carriers such as vault proteins and viral proteins.Keywords: polymeric drug carrier, non-polymeric drug carrier, gene delivery, GE drug carriers
format	article
author	Shi P Gustafson JA MacKay JA
author_facet	Shi P Gustafson JA MacKay JA
author_sort	Shi P
title	Genetically engineered nanocarriers for drug delivery
title_short	Genetically engineered nanocarriers for drug delivery
title_full	Genetically engineered nanocarriers for drug delivery
title_fullStr	Genetically engineered nanocarriers for drug delivery
title_full_unstemmed	Genetically engineered nanocarriers for drug delivery
title_sort	genetically engineered nanocarriers for drug delivery
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/0fef916374b941caa6d78bd54248732c
work_keys_str_mv	AT ship geneticallyengineerednanocarriersfordrugdelivery AT gustafsonja geneticallyengineerednanocarriersfordrugdelivery AT mackayja geneticallyengineerednanocarriersfordrugdelivery
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Genetically engineered nanocarriers for drug delivery

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