Prognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance

Lei Xue,1,&ast; Jinyuan Liu,1,&ast; Jiaheng Xie,2,&ast; Jinhua Luo1 1Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 2Department of Burn and Plastic Surgery, The First Affiliated Hospital o...

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Autores principales:	Xue L, Liu J, Xie J, Luo J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	lung adenocarcinoma transporter slc glucose metabolism immunotherapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0ff0717d4d904d489e3635eb15df114a
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spelling	oai:doaj.org-article:0ff0717d4d904d489e3635eb15df114a2021-11-18T19:40:25ZPrognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance1178-7074https://doaj.org/article/0ff0717d4d904d489e3635eb15df114a2021-11-01T00:00:00Zhttps://www.dovepress.com/prognostic-value-of-slc16a3mct4-in-lung-adenocarcinoma-and-its-clinica-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Lei Xue,1,&ast; Jinyuan Liu,1,&ast; Jiaheng Xie,2,&ast; Jinhua Luo1 1Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 2Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jinhua LuoDepartment of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of ChinaEmail luojinhua2021@163.comJiaheng XieDepartment of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of ChinaEmail xiejiaheng@njmu.edu.cnBackground: Currently, lung adenocarcinoma is the most common form of lung cancer. Although the pathogenesis of lung adenocarcinoma is progressing rapidly, the mortality rate of lung adenocarcinoma is still high. Therefore, it is necessary to search for a new biomarker to guide the prognosis of lung adenocarcinoma.Methods: The significance of SLC16A3 in lung adenocarcinoma was investigated by multi-database analysis. GEPIA, UALCAN, TIMER, Cbioportal, and R software were used for research.Results: Our study found that SLC16A3 was highly expressed in lung adenocarcinoma and was associated with poor prognosis. Further studies have shown that SLC16A3 is involved in some metabolic pathways. Not only that, SLC16A3 is associated with immune cell infiltration and tumor mutation burden (TMB).Conclusion: SLC16A3 has good prognostic significance in lung adenocarcinoma, based on which to explore treatment options may improve the prognosis of patients.Keywords: lung adenocarcinoma, transporter, SLC, glucose metabolism, immunotherapyXue LLiu JXie JLuo JDove Medical Pressarticlelung adenocarcinomatransporterslcglucose metabolismimmunotherapyMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8413-8425 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung adenocarcinoma transporter slc glucose metabolism immunotherapy Medicine (General) R5-920
spellingShingle	lung adenocarcinoma transporter slc glucose metabolism immunotherapy Medicine (General) R5-920 Xue L Liu J Xie J Luo J Prognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance
description	Lei Xue,1,&ast; Jinyuan Liu,1,&ast; Jiaheng Xie,2,&ast; Jinhua Luo1 1Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 2Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jinhua LuoDepartment of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of ChinaEmail luojinhua2021@163.comJiaheng XieDepartment of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of ChinaEmail xiejiaheng@njmu.edu.cnBackground: Currently, lung adenocarcinoma is the most common form of lung cancer. Although the pathogenesis of lung adenocarcinoma is progressing rapidly, the mortality rate of lung adenocarcinoma is still high. Therefore, it is necessary to search for a new biomarker to guide the prognosis of lung adenocarcinoma.Methods: The significance of SLC16A3 in lung adenocarcinoma was investigated by multi-database analysis. GEPIA, UALCAN, TIMER, Cbioportal, and R software were used for research.Results: Our study found that SLC16A3 was highly expressed in lung adenocarcinoma and was associated with poor prognosis. Further studies have shown that SLC16A3 is involved in some metabolic pathways. Not only that, SLC16A3 is associated with immune cell infiltration and tumor mutation burden (TMB).Conclusion: SLC16A3 has good prognostic significance in lung adenocarcinoma, based on which to explore treatment options may improve the prognosis of patients.Keywords: lung adenocarcinoma, transporter, SLC, glucose metabolism, immunotherapy
format	article
author	Xue L Liu J Xie J Luo J
author_facet	Xue L Liu J Xie J Luo J
author_sort	Xue L
title	Prognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance
title_short	Prognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance
title_full	Prognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance
title_fullStr	Prognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance
title_full_unstemmed	Prognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance
title_sort	prognostic value of slc16a3(mct4) in lung adenocarcinoma and its clinical significance
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0ff0717d4d904d489e3635eb15df114a
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Prognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance

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