Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling

Mesenchymal cells contribute to tumor angiogenesis by regulating proliferation and migration of endothelial cells. Here, the authors show that mesenchymal stem cells also have the ability to acquire an endothelial phenotype upon TGF-β stimulation via the downstream kinase JNK, and that p38α negative...

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Autores principales:	Raquel Batlle, Eva Andrés, Lorena Gonzalez, Elisabet Llonch, Ana Igea, Núria Gutierrez-Prat, Antoni Berenguer-Llergo, Angel R. Nebreda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ff11edc0a29452baa3d2896b959e5c3
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spelling	oai:doaj.org-article:0ff11edc0a29452baa3d2896b959e5c32021-12-02T15:36:05ZRegulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling10.1038/s41467-019-10946-y2041-1723https://doaj.org/article/0ff11edc0a29452baa3d2896b959e5c32019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10946-yhttps://doaj.org/toc/2041-1723Mesenchymal cells contribute to tumor angiogenesis by regulating proliferation and migration of endothelial cells. Here, the authors show that mesenchymal stem cells also have the ability to acquire an endothelial phenotype upon TGF-β stimulation via the downstream kinase JNK, and that p38α negatively regulates this process.Raquel BatlleEva AndrésLorena GonzalezElisabet LlonchAna IgeaNúria Gutierrez-PratAntoni Berenguer-LlergoAngel R. NebredaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raquel Batlle Eva Andrés Lorena Gonzalez Elisabet Llonch Ana Igea Núria Gutierrez-Prat Antoni Berenguer-Llergo Angel R. Nebreda Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
description	Mesenchymal cells contribute to tumor angiogenesis by regulating proliferation and migration of endothelial cells. Here, the authors show that mesenchymal stem cells also have the ability to acquire an endothelial phenotype upon TGF-β stimulation via the downstream kinase JNK, and that p38α negatively regulates this process.
format	article
author	Raquel Batlle Eva Andrés Lorena Gonzalez Elisabet Llonch Ana Igea Núria Gutierrez-Prat Antoni Berenguer-Llergo Angel R. Nebreda
author_facet	Raquel Batlle Eva Andrés Lorena Gonzalez Elisabet Llonch Ana Igea Núria Gutierrez-Prat Antoni Berenguer-Llergo Angel R. Nebreda
author_sort	Raquel Batlle
title	Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
title_short	Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
title_full	Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
title_fullStr	Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
title_full_unstemmed	Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
title_sort	regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through tgf-β and jnk signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0ff11edc0a29452baa3d2896b959e5c3
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Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling

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