Update on the use of dutasteride in the management of benign prostatic hypertrophy

Joe Miller, Thomas H TarterDivision of Urology, Southern Illinois University School of Medicine, Springfield, IL, USAAbstract: Benign prostatic hyperplasia (BPH) is a frequent cause of lower urinary symptoms, with a prevalence of 50% by the sixth decade of life. Hyperplasia of stromal and epithelial...

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Autores principales: Joe Miller, Thomas H Tarter
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Publicado: Dove Medical Press 2007
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Acceso en línea:https://doaj.org/article/0ff1dce861134cfd9c3abd9be8d3c16b
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spelling oai:doaj.org-article:0ff1dce861134cfd9c3abd9be8d3c16b2021-12-02T05:03:28ZUpdate on the use of dutasteride in the management of benign prostatic hypertrophy1178-1998https://doaj.org/article/0ff1dce861134cfd9c3abd9be8d3c16b2007-04-01T00:00:00Zhttps://www.dovepress.com/update-on-the-use-of-dutasteride-in-the-management-of-benign-prostatic-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Joe Miller, Thomas H TarterDivision of Urology, Southern Illinois University School of Medicine, Springfield, IL, USAAbstract: Benign prostatic hyperplasia (BPH) is a frequent cause of lower urinary symptoms, with a prevalence of 50% by the sixth decade of life. Hyperplasia of stromal and epithelial prostatic elements that surround the urethra cause lower urinary tract symptoms (LUTS), urinary tract infection, and acute urinary retention. Medical treatments of symptomatic BPH include; 1) the 5α-reductase inhibitors, 2) the α1-adrenergic antagonists, and 3) the combination of a 5α-reductase inhibitor and a α1-adrenergic antagonist. Selective α1-adrenergic antagonists relax the smooth muscle of the prostate and bladder neck without affecting the detrussor muscle of the bladder wall, thus decreasing the resistance to urine flow without compromising bladder contractility. Clinical trials have shown that α1-adrenergic antagonists decrease LUTS and increase urinary flow rates in men with symptomatic BPH, but do not reduce the long-term risk of urinary retention or need for surgical intervention. Inhibitors of 5α-reductase decrease production of dihydrotestosterone within the prostate resulting in decreased prostate volumes, increased peak urinary flow rates, improvement of symptoms, and decreased risk of acute urinary retention and need for surgical intervention. The combination of a 5α-reductase inhibitor and a α1-adrenergic antagonist reduces the clinical progression of BPH over either class of drug alone.Keywords: prostatic hyperplasia, 5α-reductase, dutasterideJoe MillerThomas H TarterDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 99-104 (2007)
institution DOAJ
collection DOAJ
language EN
topic Geriatrics
RC952-954.6
spellingShingle Geriatrics
RC952-954.6
Joe Miller
Thomas H Tarter
Update on the use of dutasteride in the management of benign prostatic hypertrophy
description Joe Miller, Thomas H TarterDivision of Urology, Southern Illinois University School of Medicine, Springfield, IL, USAAbstract: Benign prostatic hyperplasia (BPH) is a frequent cause of lower urinary symptoms, with a prevalence of 50% by the sixth decade of life. Hyperplasia of stromal and epithelial prostatic elements that surround the urethra cause lower urinary tract symptoms (LUTS), urinary tract infection, and acute urinary retention. Medical treatments of symptomatic BPH include; 1) the 5α-reductase inhibitors, 2) the α1-adrenergic antagonists, and 3) the combination of a 5α-reductase inhibitor and a α1-adrenergic antagonist. Selective α1-adrenergic antagonists relax the smooth muscle of the prostate and bladder neck without affecting the detrussor muscle of the bladder wall, thus decreasing the resistance to urine flow without compromising bladder contractility. Clinical trials have shown that α1-adrenergic antagonists decrease LUTS and increase urinary flow rates in men with symptomatic BPH, but do not reduce the long-term risk of urinary retention or need for surgical intervention. Inhibitors of 5α-reductase decrease production of dihydrotestosterone within the prostate resulting in decreased prostate volumes, increased peak urinary flow rates, improvement of symptoms, and decreased risk of acute urinary retention and need for surgical intervention. The combination of a 5α-reductase inhibitor and a α1-adrenergic antagonist reduces the clinical progression of BPH over either class of drug alone.Keywords: prostatic hyperplasia, 5α-reductase, dutasteride
format article
author Joe Miller
Thomas H Tarter
author_facet Joe Miller
Thomas H Tarter
author_sort Joe Miller
title Update on the use of dutasteride in the management of benign prostatic hypertrophy
title_short Update on the use of dutasteride in the management of benign prostatic hypertrophy
title_full Update on the use of dutasteride in the management of benign prostatic hypertrophy
title_fullStr Update on the use of dutasteride in the management of benign prostatic hypertrophy
title_full_unstemmed Update on the use of dutasteride in the management of benign prostatic hypertrophy
title_sort update on the use of dutasteride in the management of benign prostatic hypertrophy
publisher Dove Medical Press
publishDate 2007
url https://doaj.org/article/0ff1dce861134cfd9c3abd9be8d3c16b
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