INFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS

Live vaccines are used for specific brucellosis prophylaxis in the Russian Federation. These vaccines in addition to a number of positive properties have some limitations including high agglutinogenicity, reactogenicity, sensitizing activity. In this connection, the development of subunit vaccine...

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Autores principales:	V. I. Dubrovina, T. P. Starovoitova, S. A. Vityazeva, N. L. Barannikova, T. A. Ivanova, T. T. Shkaruba, S. V. Balakhonov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	adrenal gland blood stress eosinophilia thermoextract vaccine brucella abortus Science Q
Acceso en línea:	https://doaj.org/article/0ff35942be4c4b1f8ef621029e005ced
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spelling	oai:doaj.org-article:0ff35942be4c4b1f8ef621029e005ced2021-11-23T06:14:41ZINFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS2541-94202587-959610.29413/ABS.2018-3.4.15https://doaj.org/article/0ff35942be4c4b1f8ef621029e005ced2018-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/656https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Live vaccines are used for specific brucellosis prophylaxis in the Russian Federation. These vaccines in addition to a number of positive properties have some limitations including high agglutinogenicity, reactogenicity, sensitizing activity. In this connection, the development of subunit vaccines without adverse reactions is a perspective direction in modern vaccinology. Complex morphological research of the adrenal glands and comparative analysis of peripheral blood (leukogram, leukocytic index and index of allergization) of white mice immunized with thermoextracts (ТE) of Brucella abortus I-206 in L- and S-form and inactivated vaccine B. abortus 19 ВА were conducted. It was shown that ТE unlike B. abortus 19 ВА caused minor alterations in peripheral blood of the experimental animals in early periods of observation (increase of allergization index, changes in leukogram) with the subsequent levelling to the values in control. Expositions of the adrenal gland zoning were determined and cellular structure was estimated in consideration of morphometry. Changes in architectonics of the mice organ immunized with B. abortus 19 ВА were revealed. These alterations could indicate the stress-reaction development. In case of ТE application the given changes were insignificant and were developed in early periods. The revealed morphological changes in adrenal glands of laboratory animals permit to prove the necessity of realization the further experimental researches to ТE application as the components for development of a subcellular brucellosis vaccine.V. I. DubrovinaT. P. StarovoitovaS. A. VityazevaN. L. BarannikovaT. A. IvanovaT. T. ShkarubaS. V. BalakhonovScientific Сentre for Family Health and Human Reproduction Problemsarticleadrenal glandbloodstresseosinophiliathermoextractvaccinebrucella abortusScienceQRUActa Biomedica Scientifica, Vol 3, Iss 4, Pp 109-113 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	adrenal gland blood stress eosinophilia thermoextract vaccine brucella abortus Science Q
spellingShingle	adrenal gland blood stress eosinophilia thermoextract vaccine brucella abortus Science Q V. I. Dubrovina T. P. Starovoitova S. A. Vityazeva N. L. Barannikova T. A. Ivanova T. T. Shkaruba S. V. Balakhonov INFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS
description	Live vaccines are used for specific brucellosis prophylaxis in the Russian Federation. These vaccines in addition to a number of positive properties have some limitations including high agglutinogenicity, reactogenicity, sensitizing activity. In this connection, the development of subunit vaccines without adverse reactions is a perspective direction in modern vaccinology. Complex morphological research of the adrenal glands and comparative analysis of peripheral blood (leukogram, leukocytic index and index of allergization) of white mice immunized with thermoextracts (ТE) of Brucella abortus I-206 in L- and S-form and inactivated vaccine B. abortus 19 ВА were conducted. It was shown that ТE unlike B. abortus 19 ВА caused minor alterations in peripheral blood of the experimental animals in early periods of observation (increase of allergization index, changes in leukogram) with the subsequent levelling to the values in control. Expositions of the adrenal gland zoning were determined and cellular structure was estimated in consideration of morphometry. Changes in architectonics of the mice organ immunized with B. abortus 19 ВА were revealed. These alterations could indicate the stress-reaction development. In case of ТE application the given changes were insignificant and were developed in early periods. The revealed morphological changes in adrenal glands of laboratory animals permit to prove the necessity of realization the further experimental researches to ТE application as the components for development of a subcellular brucellosis vaccine.
format	article
author	V. I. Dubrovina T. P. Starovoitova S. A. Vityazeva N. L. Barannikova T. A. Ivanova T. T. Shkaruba S. V. Balakhonov
author_facet	V. I. Dubrovina T. P. Starovoitova S. A. Vityazeva N. L. Barannikova T. A. Ivanova T. T. Shkaruba S. V. Balakhonov
author_sort	V. I. Dubrovina
title	INFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS
title_short	INFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS
title_full	INFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS
title_fullStr	INFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS
title_full_unstemmed	INFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS
title_sort	influence of brucella abortus i-206 thermoextracts in l- and s-form on morphofunctional state of white mice adrenal glands
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/0ff35942be4c4b1f8ef621029e005ced
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INFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS

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