How ligand binds to the type 1 insulin-like growth factor receptor

The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like growth factor I and discuss the receptor acti...

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Autores principales:	Yibin Xu, Geoffrey K.-W. Kong, John G. Menting, Mai B. Margetts, Carlie A. Delaine, Lauren M. Jenkin, Vladislav V. Kiselyov, Pierre De Meyts, Briony E. Forbes, Michael C. Lawrence
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ffae8d861b845cfaea6faecbb96119f
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spelling	oai:doaj.org-article:0ffae8d861b845cfaea6faecbb96119f2021-12-02T14:40:55ZHow ligand binds to the type 1 insulin-like growth factor receptor10.1038/s41467-018-03219-72041-1723https://doaj.org/article/0ffae8d861b845cfaea6faecbb96119f2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03219-7https://doaj.org/toc/2041-1723The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like growth factor I and discuss the receptor activation mechanism.Yibin XuGeoffrey K.-W. KongJohn G. MentingMai B. MargettsCarlie A. DelaineLauren M. JenkinVladislav V. KiselyovPierre De MeytsBriony E. ForbesMichael C. LawrenceNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yibin Xu Geoffrey K.-W. Kong John G. Menting Mai B. Margetts Carlie A. Delaine Lauren M. Jenkin Vladislav V. Kiselyov Pierre De Meyts Briony E. Forbes Michael C. Lawrence How ligand binds to the type 1 insulin-like growth factor receptor
description	The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like growth factor I and discuss the receptor activation mechanism.
format	article
author	Yibin Xu Geoffrey K.-W. Kong John G. Menting Mai B. Margetts Carlie A. Delaine Lauren M. Jenkin Vladislav V. Kiselyov Pierre De Meyts Briony E. Forbes Michael C. Lawrence
author_facet	Yibin Xu Geoffrey K.-W. Kong John G. Menting Mai B. Margetts Carlie A. Delaine Lauren M. Jenkin Vladislav V. Kiselyov Pierre De Meyts Briony E. Forbes Michael C. Lawrence
author_sort	Yibin Xu
title	How ligand binds to the type 1 insulin-like growth factor receptor
title_short	How ligand binds to the type 1 insulin-like growth factor receptor
title_full	How ligand binds to the type 1 insulin-like growth factor receptor
title_fullStr	How ligand binds to the type 1 insulin-like growth factor receptor
title_full_unstemmed	How ligand binds to the type 1 insulin-like growth factor receptor
title_sort	how ligand binds to the type 1 insulin-like growth factor receptor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0ffae8d861b845cfaea6faecbb96119f
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How ligand binds to the type 1 insulin-like growth factor receptor

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