Genomic heterogeneity affects the response to Daylight Saving Time

Abstract Circadian clocks control the timing of many physiological events in the 24-h day. When individuals undergo an abrupt external shift (e.g., change in work schedule or travel across multiple time zones), circadian clocks become misaligned with the new time and may take several days to adjust....

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Autores principales:	Jonathan Tyler, Yu Fang, Cathy Goldstein, Daniel Forger, Srijan Sen, Margit Burmeister
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ffdbc3a109e42818220855bbe01e01e
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spelling	oai:doaj.org-article:0ffdbc3a109e42818220855bbe01e01e2021-12-02T17:55:13ZGenomic heterogeneity affects the response to Daylight Saving Time10.1038/s41598-021-94459-z2045-2322https://doaj.org/article/0ffdbc3a109e42818220855bbe01e01e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94459-zhttps://doaj.org/toc/2045-2322Abstract Circadian clocks control the timing of many physiological events in the 24-h day. When individuals undergo an abrupt external shift (e.g., change in work schedule or travel across multiple time zones), circadian clocks become misaligned with the new time and may take several days to adjust. Chronic circadian misalignment, e.g., as a result of shift work, has been shown to lead to several physical and mental health problems. Despite the serious health implications of circadian misalignment, relatively little is known about how genetic variation affects an individual’s ability to entrain to abrupt external changes. Accordingly, we used the one-hour advance from the onset of daylight saving time (DST) as a natural experiment to comprehensively study how individual heterogeneity affects the shift of sleep/wake cycles in response to an abrupt external time change. We found that individuals genetically predisposed to a morning tendency adjusted to the advance in a few days, while genetically predisposed evening-inclined individuals had not shifted. Observing differential effects by genetic disposition after a one-hour advance underscores the importance of heterogeneity in adaptation to external schedule shifts. These genetic differences may affect how individuals adjust to jet lag or shift work as well.Jonathan TylerYu FangCathy GoldsteinDaniel ForgerSrijan SenMargit BurmeisterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jonathan Tyler Yu Fang Cathy Goldstein Daniel Forger Srijan Sen Margit Burmeister Genomic heterogeneity affects the response to Daylight Saving Time
description	Abstract Circadian clocks control the timing of many physiological events in the 24-h day. When individuals undergo an abrupt external shift (e.g., change in work schedule or travel across multiple time zones), circadian clocks become misaligned with the new time and may take several days to adjust. Chronic circadian misalignment, e.g., as a result of shift work, has been shown to lead to several physical and mental health problems. Despite the serious health implications of circadian misalignment, relatively little is known about how genetic variation affects an individual’s ability to entrain to abrupt external changes. Accordingly, we used the one-hour advance from the onset of daylight saving time (DST) as a natural experiment to comprehensively study how individual heterogeneity affects the shift of sleep/wake cycles in response to an abrupt external time change. We found that individuals genetically predisposed to a morning tendency adjusted to the advance in a few days, while genetically predisposed evening-inclined individuals had not shifted. Observing differential effects by genetic disposition after a one-hour advance underscores the importance of heterogeneity in adaptation to external schedule shifts. These genetic differences may affect how individuals adjust to jet lag or shift work as well.
format	article
author	Jonathan Tyler Yu Fang Cathy Goldstein Daniel Forger Srijan Sen Margit Burmeister
author_facet	Jonathan Tyler Yu Fang Cathy Goldstein Daniel Forger Srijan Sen Margit Burmeister
author_sort	Jonathan Tyler
title	Genomic heterogeneity affects the response to Daylight Saving Time
title_short	Genomic heterogeneity affects the response to Daylight Saving Time
title_full	Genomic heterogeneity affects the response to Daylight Saving Time
title_fullStr	Genomic heterogeneity affects the response to Daylight Saving Time
title_full_unstemmed	Genomic heterogeneity affects the response to Daylight Saving Time
title_sort	genomic heterogeneity affects the response to daylight saving time
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0ffdbc3a109e42818220855bbe01e01e
work_keys_str_mv	AT jonathantyler genomicheterogeneityaffectstheresponsetodaylightsavingtime AT yufang genomicheterogeneityaffectstheresponsetodaylightsavingtime AT cathygoldstein genomicheterogeneityaffectstheresponsetodaylightsavingtime AT danielforger genomicheterogeneityaffectstheresponsetodaylightsavingtime AT srijansen genomicheterogeneityaffectstheresponsetodaylightsavingtime AT margitburmeister genomicheterogeneityaffectstheresponsetodaylightsavingtime
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Genomic heterogeneity affects the response to Daylight Saving Time

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