KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

The KL-VS haplotype of the Klotho gene has been associated with reduced risk of Alzheimer’s disease and dementia. Here the authors show an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data.

Guardado en:

Detalles Bibliográficos
Autores principales:	Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Rainer Malik, Michael Ewers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ffe3664dd584e458ee1ba0a49270e64
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0ffe3664dd584e458ee1ba0a49270e64
record_format	dspace
spelling	oai:doaj.org-article:0ffe3664dd584e458ee1ba0a49270e642021-12-02T17:44:59ZKL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease10.1038/s41467-021-23755-z2041-1723https://doaj.org/article/0ffe3664dd584e458ee1ba0a49270e642021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23755-zhttps://doaj.org/toc/2041-1723The KL-VS haplotype of the Klotho gene has been associated with reduced risk of Alzheimer’s disease and dementia. Here the authors show an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data.Julia NeitzelNicolai FranzmeierAnna RubinskiMartin DichgansMatthias BrendelAlzheimer’s Disease Neuroimaging Initiative (ADNI)Rainer MalikMichael EwersNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia Neitzel Nicolai Franzmeier Anna Rubinski Martin Dichgans Matthias Brendel Alzheimer’s Disease Neuroimaging Initiative (ADNI) Rainer Malik Michael Ewers KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease
description	The KL-VS haplotype of the Klotho gene has been associated with reduced risk of Alzheimer’s disease and dementia. Here the authors show an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data.
format	article
author	Julia Neitzel Nicolai Franzmeier Anna Rubinski Martin Dichgans Matthias Brendel Alzheimer’s Disease Neuroimaging Initiative (ADNI) Rainer Malik Michael Ewers
author_facet	Julia Neitzel Nicolai Franzmeier Anna Rubinski Martin Dichgans Matthias Brendel Alzheimer’s Disease Neuroimaging Initiative (ADNI) Rainer Malik Michael Ewers
author_sort	Julia Neitzel
title	KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease
title_short	KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease
title_full	KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease
title_fullStr	KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease
title_full_unstemmed	KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease
title_sort	kl-vs heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0ffe3664dd584e458ee1ba0a49270e64
work_keys_str_mv	AT julianeitzel klvsheterozygosityisassociatedwithloweramyloiddependenttauaccumulationandmemoryimpairmentinalzheimersdisease AT nicolaifranzmeier klvsheterozygosityisassociatedwithloweramyloiddependenttauaccumulationandmemoryimpairmentinalzheimersdisease AT annarubinski klvsheterozygosityisassociatedwithloweramyloiddependenttauaccumulationandmemoryimpairmentinalzheimersdisease AT martindichgans klvsheterozygosityisassociatedwithloweramyloiddependenttauaccumulationandmemoryimpairmentinalzheimersdisease AT matthiasbrendel klvsheterozygosityisassociatedwithloweramyloiddependenttauaccumulationandmemoryimpairmentinalzheimersdisease AT alzheimersdiseaseneuroimaginginitiativeadni klvsheterozygosityisassociatedwithloweramyloiddependenttauaccumulationandmemoryimpairmentinalzheimersdisease AT rainermalik klvsheterozygosityisassociatedwithloweramyloiddependenttauaccumulationandmemoryimpairmentinalzheimersdisease AT michaelewers klvsheterozygosityisassociatedwithloweramyloiddependenttauaccumulationandmemoryimpairmentinalzheimersdisease
_version_	1718379569963073536

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

Ejemplares similares