Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.

Amyloid precursor protein (APP) is a transmembrane glycoprotein frequently studied for its role in Alzheimer's disease. Our recent study in APP knockout (KO) mice identified an important role for APP in modulating normal neuronal development in the retina. However the role APP plays in the adul...

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Autores principales:	Tracy Ho, Kirstan A Vessey, Roberto Cappai, Virginie Dinet, Frédéric Mascarelli, Giuseppe D Ciccotosto, Erica L Fletcher
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10002006621145f0a3275bafc4d891b7
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spelling	oai:doaj.org-article:10002006621145f0a3275bafc4d891b72021-11-18T07:29:57ZAmyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.1932-620310.1371/journal.pone.0029892https://doaj.org/article/10002006621145f0a3275bafc4d891b72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22279552/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Amyloid precursor protein (APP) is a transmembrane glycoprotein frequently studied for its role in Alzheimer's disease. Our recent study in APP knockout (KO) mice identified an important role for APP in modulating normal neuronal development in the retina. However the role APP plays in the adult retina and whether it is required for vision is unknown. In this study we evaluated the role of APP in retinal function and morphology comparing adult wildtype (WT) and APP-KO mice. APP was expressed on neuronal cells of the inner retina, including horizontal, cone bipolar, amacrine and ganglion cells in WT mice. The function of the retina was assessed using the electroretinogram and although the rod photoreceptor responses were similar in APP-KO and WT mice, the post-photoreceptor, inner retinal responses of both the rod and cone pathways were reduced in APP-KO mice. These changes in inner retinal function did not translate to a substantial change in visual acuity as assessed using the optokinetic response or to changes in the gross cellular structure of the retina. These findings indicate that APP is not required for basic visual function, but that it is involved in modulating inner retinal circuitry.Tracy HoKirstan A VesseyRoberto CappaiVirginie DinetFrédéric MascarelliGiuseppe D CiccotostoErica L FletcherPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29892 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tracy Ho Kirstan A Vessey Roberto Cappai Virginie Dinet Frédéric Mascarelli Giuseppe D Ciccotosto Erica L Fletcher Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.
description	Amyloid precursor protein (APP) is a transmembrane glycoprotein frequently studied for its role in Alzheimer's disease. Our recent study in APP knockout (KO) mice identified an important role for APP in modulating normal neuronal development in the retina. However the role APP plays in the adult retina and whether it is required for vision is unknown. In this study we evaluated the role of APP in retinal function and morphology comparing adult wildtype (WT) and APP-KO mice. APP was expressed on neuronal cells of the inner retina, including horizontal, cone bipolar, amacrine and ganglion cells in WT mice. The function of the retina was assessed using the electroretinogram and although the rod photoreceptor responses were similar in APP-KO and WT mice, the post-photoreceptor, inner retinal responses of both the rod and cone pathways were reduced in APP-KO mice. These changes in inner retinal function did not translate to a substantial change in visual acuity as assessed using the optokinetic response or to changes in the gross cellular structure of the retina. These findings indicate that APP is not required for basic visual function, but that it is involved in modulating inner retinal circuitry.
format	article
author	Tracy Ho Kirstan A Vessey Roberto Cappai Virginie Dinet Frédéric Mascarelli Giuseppe D Ciccotosto Erica L Fletcher
author_facet	Tracy Ho Kirstan A Vessey Roberto Cappai Virginie Dinet Frédéric Mascarelli Giuseppe D Ciccotosto Erica L Fletcher
author_sort	Tracy Ho
title	Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.
title_short	Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.
title_full	Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.
title_fullStr	Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.
title_full_unstemmed	Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.
title_sort	amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/10002006621145f0a3275bafc4d891b7
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Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina.

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