CYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA

The study involved 56 patients with chronic obstructive pulmonary disease (COPD), stage III-IV, 38 patients with severe bronchial asthma (BA), and 45 patients with a combination of COPD stage III-IV and bronchial asthma at exacerbation period. In all the patients, we have measured blood levels of pr...

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Autores principales:	T. G. Shapovalova, M. V. Volkova, N. V. Shelobanova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	copd bronchial asthma cytokines cell adhesion molecules myocardial contractile function Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/10048ff8ed1a4b7187f99f46cc50565c
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spelling	oai:doaj.org-article:10048ff8ed1a4b7187f99f46cc50565c2021-11-18T08:03:41ZCYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2010-6-553-558https://doaj.org/article/10048ff8ed1a4b7187f99f46cc50565c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/472https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe study involved 56 patients with chronic obstructive pulmonary disease (COPD), stage III-IV, 38 patients with severe bronchial asthma (BA), and 45 patients with a combination of COPD stage III-IV and bronchial asthma at exacerbation period. In all the patients, we have measured blood levels of pro-inflammatory (IL-6, IL -8, TNFα) and anti-inflammatory (IL-4) cytokines, amounts of cell adhesion molecules (ICAM- 1, VCAM-1), along with assessment of contractile myocardial functional disorders by means of Doppler echocardiography. Highest rates of pro-inflammatory cytokines and adhesion molecules were found in the group of patients with combined pathology, along with most significant signs of myocardial hypertrophy, both in right and left heart compartments, accompanied by a decrease in contractile myocardial function.T. G. ShapovalovaM. V. VolkovaN. V. ShelobanovaSPb RAACIarticlecopdbronchial asthmacytokinescell adhesion moleculesmyocardial contractile functionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 6, Pp 553-558 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	copd bronchial asthma cytokines cell adhesion molecules myocardial contractile function Immunologic diseases. Allergy RC581-607
spellingShingle	copd bronchial asthma cytokines cell adhesion molecules myocardial contractile function Immunologic diseases. Allergy RC581-607 T. G. Shapovalova M. V. Volkova N. V. Shelobanova CYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA
description	The study involved 56 patients with chronic obstructive pulmonary disease (COPD), stage III-IV, 38 patients with severe bronchial asthma (BA), and 45 patients with a combination of COPD stage III-IV and bronchial asthma at exacerbation period. In all the patients, we have measured blood levels of pro-inflammatory (IL-6, IL -8, TNFα) and anti-inflammatory (IL-4) cytokines, amounts of cell adhesion molecules (ICAM- 1, VCAM-1), along with assessment of contractile myocardial functional disorders by means of Doppler echocardiography. Highest rates of pro-inflammatory cytokines and adhesion molecules were found in the group of patients with combined pathology, along with most significant signs of myocardial hypertrophy, both in right and left heart compartments, accompanied by a decrease in contractile myocardial function.
format	article
author	T. G. Shapovalova M. V. Volkova N. V. Shelobanova
author_facet	T. G. Shapovalova M. V. Volkova N. V. Shelobanova
author_sort	T. G. Shapovalova
title	CYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA
title_short	CYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA
title_full	CYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA
title_fullStr	CYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA
title_full_unstemmed	CYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA
title_sort	cytokine profile and adhesion molecules in the patients with chronic obstructive lung disease combined with bronchial asthma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/10048ff8ed1a4b7187f99f46cc50565c
work_keys_str_mv	AT tgshapovalova cytokineprofileandadhesionmoleculesinthepatientswithchronicobstructivelungdiseasecombinedwithbronchialasthma AT mvvolkova cytokineprofileandadhesionmoleculesinthepatientswithchronicobstructivelungdiseasecombinedwithbronchialasthma AT nvshelobanova cytokineprofileandadhesionmoleculesinthepatientswithchronicobstructivelungdiseasecombinedwithbronchialasthma
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CYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA

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