Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metabolic adaptation after myocardial infarction.

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Autores principales:	Lukas S. Tombor, David John, Simone F. Glaser, Guillermo Luxán, Elvira Forte, Milena Furtado, Nadia Rosenthal, Nina Baumgarten, Marcel H. Schulz, Janina Wittig, Eva-Maria Rogg, Yosif Manavski, Ariane Fischer, Marion Muhly-Reinholz, Kathrin Klee, Mario Looso, Carmen Selignow, Till Acker, Sofia-Iris Bibli, Ingrid Fleming, Ralph Patrick, Richard P. Harvey, Wesley T. Abplanalp, Stefanie Dimmeler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1006b6d795e44cc8b2756328c762cb7b
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spelling	oai:doaj.org-article:1006b6d795e44cc8b2756328c762cb7b2021-12-02T13:57:32ZSingle cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction10.1038/s41467-021-20905-12041-1723https://doaj.org/article/1006b6d795e44cc8b2756328c762cb7b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20905-1https://doaj.org/toc/2041-1723Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metabolic adaptation after myocardial infarction.Lukas S. TomborDavid JohnSimone F. GlaserGuillermo LuxánElvira ForteMilena FurtadoNadia RosenthalNina BaumgartenMarcel H. SchulzJanina WittigEva-Maria RoggYosif ManavskiAriane FischerMarion Muhly-ReinholzKathrin KleeMario LoosoCarmen SelignowTill AckerSofia-Iris BibliIngrid FlemingRalph PatrickRichard P. HarveyWesley T. AbplanalpStefanie DimmelerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lukas S. Tombor David John Simone F. Glaser Guillermo Luxán Elvira Forte Milena Furtado Nadia Rosenthal Nina Baumgarten Marcel H. Schulz Janina Wittig Eva-Maria Rogg Yosif Manavski Ariane Fischer Marion Muhly-Reinholz Kathrin Klee Mario Looso Carmen Selignow Till Acker Sofia-Iris Bibli Ingrid Fleming Ralph Patrick Richard P. Harvey Wesley T. Abplanalp Stefanie Dimmeler Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
description	Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metabolic adaptation after myocardial infarction.
format	article
author	Lukas S. Tombor David John Simone F. Glaser Guillermo Luxán Elvira Forte Milena Furtado Nadia Rosenthal Nina Baumgarten Marcel H. Schulz Janina Wittig Eva-Maria Rogg Yosif Manavski Ariane Fischer Marion Muhly-Reinholz Kathrin Klee Mario Looso Carmen Selignow Till Acker Sofia-Iris Bibli Ingrid Fleming Ralph Patrick Richard P. Harvey Wesley T. Abplanalp Stefanie Dimmeler
author_facet	Lukas S. Tombor David John Simone F. Glaser Guillermo Luxán Elvira Forte Milena Furtado Nadia Rosenthal Nina Baumgarten Marcel H. Schulz Janina Wittig Eva-Maria Rogg Yosif Manavski Ariane Fischer Marion Muhly-Reinholz Kathrin Klee Mario Looso Carmen Selignow Till Acker Sofia-Iris Bibli Ingrid Fleming Ralph Patrick Richard P. Harvey Wesley T. Abplanalp Stefanie Dimmeler
author_sort	Lukas S. Tombor
title	Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
title_short	Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
title_full	Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
title_fullStr	Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
title_full_unstemmed	Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
title_sort	single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1006b6d795e44cc8b2756328c762cb7b
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Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

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