Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development
Tet-mediated DNA demethylation is intimately involved in reguatling embryonic development. Here the authors characterise DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice and provide evidence that Tet-mediated DNA demethylation plays a role in re...
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/100780c789c64844afdc6a69f48c6de2 |
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oai:doaj.org-article:100780c789c64844afdc6a69f48c6de22021-12-02T17:31:21ZTet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development10.1038/s41467-019-12325-z2041-1723https://doaj.org/article/100780c789c64844afdc6a69f48c6de22019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12325-zhttps://doaj.org/toc/2041-1723Tet-mediated DNA demethylation is intimately involved in reguatling embryonic development. Here the authors characterise DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice and provide evidence that Tet-mediated DNA demethylation plays a role in regulating chromatin organization during early heart development.Shaohai FangJia LiYang XiaoMinjung LeeLei GuoWei HanTingting LiMatthew C. HillTingting HongWilliam MoRang XuPing ZhangFen WangJiang ChangYubin ZhouDeqiang SunJames F. MartinYun HuangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Shaohai Fang Jia Li Yang Xiao Minjung Lee Lei Guo Wei Han Tingting Li Matthew C. Hill Tingting Hong William Mo Rang Xu Ping Zhang Fen Wang Jiang Chang Yubin Zhou Deqiang Sun James F. Martin Yun Huang Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development |
| description |
Tet-mediated DNA demethylation is intimately involved in reguatling embryonic development. Here the authors characterise DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice and provide evidence that Tet-mediated DNA demethylation plays a role in regulating chromatin organization during early heart development. |
| format |
article |
| author |
Shaohai Fang Jia Li Yang Xiao Minjung Lee Lei Guo Wei Han Tingting Li Matthew C. Hill Tingting Hong William Mo Rang Xu Ping Zhang Fen Wang Jiang Chang Yubin Zhou Deqiang Sun James F. Martin Yun Huang |
| author_facet |
Shaohai Fang Jia Li Yang Xiao Minjung Lee Lei Guo Wei Han Tingting Li Matthew C. Hill Tingting Hong William Mo Rang Xu Ping Zhang Fen Wang Jiang Chang Yubin Zhou Deqiang Sun James F. Martin Yun Huang |
| author_sort |
Shaohai Fang |
| title |
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development |
| title_short |
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development |
| title_full |
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development |
| title_fullStr |
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development |
| title_full_unstemmed |
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development |
| title_sort |
tet inactivation disrupts yy1 binding and long-range chromatin interactions during embryonic heart development |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/100780c789c64844afdc6a69f48c6de2 |
| work_keys_str_mv |
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| _version_ |
1718380595184140288 |