Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates kinesin-1 and increases robustness of kinesin-1 st...

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Autores principales:	Verena Henrichs, Lenka Grycova, Cyril Barinka, Zuzana Nahacka, Jiri Neuzil, Stefan Diez, Jakub Rohlena, Marcus Braun, Zdenek Lansky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/100a9a30842b49bfb6e6362c1f4832c1
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id	oai:doaj.org-article:100a9a30842b49bfb6e6362c1f4832c1
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spelling	oai:doaj.org-article:100a9a30842b49bfb6e6362c1f4832c12021-12-02T17:39:44ZMitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments10.1038/s41467-020-16972-52041-1723https://doaj.org/article/100a9a30842b49bfb6e6362c1f4832c12020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16972-5https://doaj.org/toc/2041-1723Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates kinesin-1 and increases robustness of kinesin-1 stepping on crowded microtubule surfaces.Verena HenrichsLenka GrycovaCyril BarinkaZuzana NahackaJiri NeuzilStefan DiezJakub RohlenaMarcus BraunZdenek LanskyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Verena Henrichs Lenka Grycova Cyril Barinka Zuzana Nahacka Jiri Neuzil Stefan Diez Jakub Rohlena Marcus Braun Zdenek Lansky Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
description	Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates kinesin-1 and increases robustness of kinesin-1 stepping on crowded microtubule surfaces.
format	article
author	Verena Henrichs Lenka Grycova Cyril Barinka Zuzana Nahacka Jiri Neuzil Stefan Diez Jakub Rohlena Marcus Braun Zdenek Lansky
author_facet	Verena Henrichs Lenka Grycova Cyril Barinka Zuzana Nahacka Jiri Neuzil Stefan Diez Jakub Rohlena Marcus Braun Zdenek Lansky
author_sort	Verena Henrichs
title	Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
title_short	Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
title_full	Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
title_fullStr	Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
title_full_unstemmed	Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
title_sort	mitochondria-adaptor trak1 promotes kinesin-1 driven transport in crowded environments
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/100a9a30842b49bfb6e6362c1f4832c1
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Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

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