Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles

Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles

Extracellular vesicles can carry immunoregulatory cytokines such as TGF-β. Here the authors use CD11b-deficient mice and macrophages to show that such vesicles carrying TGF-β are produced in response to Candida albicans infections and can limit the proinflammatory response partly via a positive feed...

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Autores principales: Luke D. Halder, Emeraldo A. H. Jo, Mohammad Z. Hasan, Marta Ferreira-Gomes, Thomas Krüger, Martin Westermann, Diana I. Palme, Günter Rambach, Niklas Beyersdorf, Cornelia Speth, Ilse D. Jacobsen, Olaf Kniemeyer, Berit Jungnickel, Peter F. Zipfel, Christine Skerka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/100b9457afd440a39a41c6760279cbb2
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Sumario:Extracellular vesicles can carry immunoregulatory cytokines such as TGF-β. Here the authors use CD11b-deficient mice and macrophages to show that such vesicles carrying TGF-β are produced in response to Candida albicans infections and can limit the proinflammatory response partly via a positive feedback on TGF-β production by endothelial cells.

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