Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles

Extracellular vesicles can carry immunoregulatory cytokines such as TGF-β. Here the authors use CD11b-deficient mice and macrophages to show that such vesicles carrying TGF-β are produced in response to Candida albicans infections and can limit the proinflammatory response partly via a positive feed...

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Autores principales:	Luke D. Halder, Emeraldo A. H. Jo, Mohammad Z. Hasan, Marta Ferreira-Gomes, Thomas Krüger, Martin Westermann, Diana I. Palme, Günter Rambach, Niklas Beyersdorf, Cornelia Speth, Ilse D. Jacobsen, Olaf Kniemeyer, Berit Jungnickel, Peter F. Zipfel, Christine Skerka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/100b9457afd440a39a41c6760279cbb2
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spelling	oai:doaj.org-article:100b9457afd440a39a41c6760279cbb22021-12-02T16:51:03ZImmune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles10.1038/s41467-020-16241-52041-1723https://doaj.org/article/100b9457afd440a39a41c6760279cbb22020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16241-5https://doaj.org/toc/2041-1723Extracellular vesicles can carry immunoregulatory cytokines such as TGF-β. Here the authors use CD11b-deficient mice and macrophages to show that such vesicles carrying TGF-β are produced in response to Candida albicans infections and can limit the proinflammatory response partly via a positive feedback on TGF-β production by endothelial cells.Luke D. HalderEmeraldo A. H. JoMohammad Z. HasanMarta Ferreira-GomesThomas KrügerMartin WestermannDiana I. PalmeGünter RambachNiklas BeyersdorfCornelia SpethIlse D. JacobsenOlaf KniemeyerBerit JungnickelPeter F. ZipfelChristine SkerkaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luke D. Halder Emeraldo A. H. Jo Mohammad Z. Hasan Marta Ferreira-Gomes Thomas Krüger Martin Westermann Diana I. Palme Günter Rambach Niklas Beyersdorf Cornelia Speth Ilse D. Jacobsen Olaf Kniemeyer Berit Jungnickel Peter F. Zipfel Christine Skerka Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles
description	Extracellular vesicles can carry immunoregulatory cytokines such as TGF-β. Here the authors use CD11b-deficient mice and macrophages to show that such vesicles carrying TGF-β are produced in response to Candida albicans infections and can limit the proinflammatory response partly via a positive feedback on TGF-β production by endothelial cells.
format	article
author	Luke D. Halder Emeraldo A. H. Jo Mohammad Z. Hasan Marta Ferreira-Gomes Thomas Krüger Martin Westermann Diana I. Palme Günter Rambach Niklas Beyersdorf Cornelia Speth Ilse D. Jacobsen Olaf Kniemeyer Berit Jungnickel Peter F. Zipfel Christine Skerka
author_facet	Luke D. Halder Emeraldo A. H. Jo Mohammad Z. Hasan Marta Ferreira-Gomes Thomas Krüger Martin Westermann Diana I. Palme Günter Rambach Niklas Beyersdorf Cornelia Speth Ilse D. Jacobsen Olaf Kniemeyer Berit Jungnickel Peter F. Zipfel Christine Skerka
author_sort	Luke D. Halder
title	Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles
title_short	Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles
title_full	Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles
title_fullStr	Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles
title_full_unstemmed	Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles
title_sort	immune modulation by complement receptor 3-dependent human monocyte tgf-β1-transporting vesicles
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/100b9457afd440a39a41c6760279cbb2
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Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles

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