Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo

Abstract Early pregnancy is a critical time for successful reproduction; up to half of human pregnancies fail before the development of the definitive chorioallantoic placenta. Unlike the situation in eutherian mammals, marsupial pregnancy is characterised by a long pre-implantation period prior to...

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Autores principales:	Camilla M. Whittington, Denis O’Meally, Melanie K. Laird, Katherine Belov, Michael B. Thompson, Bronwyn M. McAllan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/100d0c847f5b475c9143307b222e8f6d
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spelling	oai:doaj.org-article:100d0c847f5b475c9143307b222e8f6d2021-12-02T15:08:57ZTranscriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo10.1038/s41598-018-20744-z2045-2322https://doaj.org/article/100d0c847f5b475c9143307b222e8f6d2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20744-zhttps://doaj.org/toc/2045-2322Abstract Early pregnancy is a critical time for successful reproduction; up to half of human pregnancies fail before the development of the definitive chorioallantoic placenta. Unlike the situation in eutherian mammals, marsupial pregnancy is characterised by a long pre-implantation period prior to the development of the short-lived placenta, making them ideal models for study of the uterine environment promoting embryonic survival pre-implantation. Here we present a transcriptomic study of pre-implantation marsupial pregnancy, and identify differentially expressed genes in the Sminthopsis crassicaudata uterus involved in metabolism and biosynthesis, transport, immunity, tissue remodelling, and uterine receptivity. Interestingly, almost one quarter of the top 50 genes that are differentially upregulated in early pregnancy are putatively involved in histotrophy, highlighting the importance of nutrient transport to the conceptus prior to the development of the placenta. This work furthers our understanding of the mechanisms underlying survival of pre-implantation embryos in the earliest live bearing ancestors of mammals.Camilla M. WhittingtonDenis O’MeallyMelanie K. LairdKatherine BelovMichael B. ThompsonBronwyn M. McAllanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Camilla M. Whittington Denis O’Meally Melanie K. Laird Katherine Belov Michael B. Thompson Bronwyn M. McAllan Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo
description	Abstract Early pregnancy is a critical time for successful reproduction; up to half of human pregnancies fail before the development of the definitive chorioallantoic placenta. Unlike the situation in eutherian mammals, marsupial pregnancy is characterised by a long pre-implantation period prior to the development of the short-lived placenta, making them ideal models for study of the uterine environment promoting embryonic survival pre-implantation. Here we present a transcriptomic study of pre-implantation marsupial pregnancy, and identify differentially expressed genes in the Sminthopsis crassicaudata uterus involved in metabolism and biosynthesis, transport, immunity, tissue remodelling, and uterine receptivity. Interestingly, almost one quarter of the top 50 genes that are differentially upregulated in early pregnancy are putatively involved in histotrophy, highlighting the importance of nutrient transport to the conceptus prior to the development of the placenta. This work furthers our understanding of the mechanisms underlying survival of pre-implantation embryos in the earliest live bearing ancestors of mammals.
format	article
author	Camilla M. Whittington Denis O’Meally Melanie K. Laird Katherine Belov Michael B. Thompson Bronwyn M. McAllan
author_facet	Camilla M. Whittington Denis O’Meally Melanie K. Laird Katherine Belov Michael B. Thompson Bronwyn M. McAllan
author_sort	Camilla M. Whittington
title	Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo
title_short	Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo
title_full	Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo
title_fullStr	Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo
title_full_unstemmed	Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo
title_sort	transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/100d0c847f5b475c9143307b222e8f6d
work_keys_str_mv	AT camillamwhittington transcriptomicchangesinthepreimplantationuterushighlighthistotrophicnutritionofthedevelopingmarsupialembryo AT denisomeally transcriptomicchangesinthepreimplantationuterushighlighthistotrophicnutritionofthedevelopingmarsupialembryo AT melanieklaird transcriptomicchangesinthepreimplantationuterushighlighthistotrophicnutritionofthedevelopingmarsupialembryo AT katherinebelov transcriptomicchangesinthepreimplantationuterushighlighthistotrophicnutritionofthedevelopingmarsupialembryo AT michaelbthompson transcriptomicchangesinthepreimplantationuterushighlighthistotrophicnutritionofthedevelopingmarsupialembryo AT bronwynmmcallan transcriptomicchangesinthepreimplantationuterushighlighthistotrophicnutritionofthedevelopingmarsupialembryo
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Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo

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