Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study

Bariatric surgery improves obesity-related comorbidities. Methylarginines are biomarkers of cardiometabolic risk, liver steatosis, and insulin resistance. Here, we aimed to investigate methylarginines in obese patients undergoing bariatric surgery and compared them to age- and sex-matched healthy su...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Julie Poirier, Chloé Cloteau, Audrey Aguesse, Xavier Billot, Etienne Thévenot, Michel Krempf, René Valéro, Marie Maraninchi, Mikaël Croyal
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bariatric surgery ADMA SDMA NMMA DMGV methylarginines Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/100e0038ff6c4e0eb66208eee4768b3a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:100e0038ff6c4e0eb66208eee4768b3a
record_format	dspace
spelling	oai:doaj.org-article:100e0038ff6c4e0eb66208eee4768b3a2021-11-25T18:20:42ZBariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study10.3390/metabo111107592218-1989https://doaj.org/article/100e0038ff6c4e0eb66208eee4768b3a2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/759https://doaj.org/toc/2218-1989Bariatric surgery improves obesity-related comorbidities. Methylarginines are biomarkers of cardiometabolic risk, liver steatosis, and insulin resistance. Here, we aimed to investigate methylarginines in obese patients undergoing bariatric surgery and compared them to age- and sex-matched healthy subjects. Thirty-one obese patients who underwent bariatric surgery and 31 healthy individuals were used for this retrospective study. The basal serum methylarginine levels were determined in the healthy individuals and the obese patients, before surgery and 6 and 12 months after surgery, by mass spectrometry. Compared with the healthy individuals, the obese patients displayed elevated monomethylarginine (mean change: +95%, <i>p</i> < 0.001), asymmetric-dimethylarginine (+105%, <i>p</i> < 0.001), symmetric-dimethylarginine (+25%, <i>p</i> = 0.003), and dimethylguanidino valerate (+32%, <i>p</i> = 0.008) concentrations. Bariatric surgery durably reduced the body mass index by 28% (12 months, 95%CI: 24–33, <i>p</i> = 0.002) and improved plasma lipids, insulin resistance, and liver function. Bariatric surgery reduced the serum levels of monomethylarginine and asymmetric-dimethylarginine by 12% (95%CI: 6–17) and 36% (95%CI: 27–45) (12 months, <i>p</i> = 0.003), respectively, but not symmetric-dimethylarginine or dimethylguanidino valerate. The monomethylarginine and asymmetric-dimethylarginine concentrations were strongly correlated with markers of dyslipidemia, insulin resistance, and a fatty liver. Serum dimethylguanidino valerate was primarily correlated with glycemia and renal function, whereas serum symmetric-dimethylarginine was almost exclusively associated with renal function. In conclusion, the monomethylarginine and asymmetric-dimethylarginine levels are efficiently decreased by bariatric surgery, leading to a reduced atherogenic profile in obese patients. Methylarginines follow different metabolic patterns, which could help for the stratification of cardiometabolic disorders in obese patients.Julie PoirierChloé CloteauAudrey AguesseXavier BillotEtienne ThévenotMichel KrempfRené ValéroMarie MaraninchiMikaël CroyalMDPI AGarticlebariatric surgeryADMASDMANMMADMGVmethylargininesMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 759, p 759 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bariatric surgery ADMA SDMA NMMA DMGV methylarginines Microbiology QR1-502
spellingShingle	bariatric surgery ADMA SDMA NMMA DMGV methylarginines Microbiology QR1-502 Julie Poirier Chloé Cloteau Audrey Aguesse Xavier Billot Etienne Thévenot Michel Krempf René Valéro Marie Maraninchi Mikaël Croyal Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study
description	Bariatric surgery improves obesity-related comorbidities. Methylarginines are biomarkers of cardiometabolic risk, liver steatosis, and insulin resistance. Here, we aimed to investigate methylarginines in obese patients undergoing bariatric surgery and compared them to age- and sex-matched healthy subjects. Thirty-one obese patients who underwent bariatric surgery and 31 healthy individuals were used for this retrospective study. The basal serum methylarginine levels were determined in the healthy individuals and the obese patients, before surgery and 6 and 12 months after surgery, by mass spectrometry. Compared with the healthy individuals, the obese patients displayed elevated monomethylarginine (mean change: +95%, <i>p</i> < 0.001), asymmetric-dimethylarginine (+105%, <i>p</i> < 0.001), symmetric-dimethylarginine (+25%, <i>p</i> = 0.003), and dimethylguanidino valerate (+32%, <i>p</i> = 0.008) concentrations. Bariatric surgery durably reduced the body mass index by 28% (12 months, 95%CI: 24–33, <i>p</i> = 0.002) and improved plasma lipids, insulin resistance, and liver function. Bariatric surgery reduced the serum levels of monomethylarginine and asymmetric-dimethylarginine by 12% (95%CI: 6–17) and 36% (95%CI: 27–45) (12 months, <i>p</i> = 0.003), respectively, but not symmetric-dimethylarginine or dimethylguanidino valerate. The monomethylarginine and asymmetric-dimethylarginine concentrations were strongly correlated with markers of dyslipidemia, insulin resistance, and a fatty liver. Serum dimethylguanidino valerate was primarily correlated with glycemia and renal function, whereas serum symmetric-dimethylarginine was almost exclusively associated with renal function. In conclusion, the monomethylarginine and asymmetric-dimethylarginine levels are efficiently decreased by bariatric surgery, leading to a reduced atherogenic profile in obese patients. Methylarginines follow different metabolic patterns, which could help for the stratification of cardiometabolic disorders in obese patients.
format	article
author	Julie Poirier Chloé Cloteau Audrey Aguesse Xavier Billot Etienne Thévenot Michel Krempf René Valéro Marie Maraninchi Mikaël Croyal
author_facet	Julie Poirier Chloé Cloteau Audrey Aguesse Xavier Billot Etienne Thévenot Michel Krempf René Valéro Marie Maraninchi Mikaël Croyal
author_sort	Julie Poirier
title	Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study
title_short	Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study
title_full	Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study
title_fullStr	Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study
title_full_unstemmed	Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study
title_sort	bariatric surgery improves the atherogenic profile of circulating methylarginines in obese patients: results from a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/100e0038ff6c4e0eb66208eee4768b3a
work_keys_str_mv	AT juliepoirier bariatricsurgeryimprovestheatherogenicprofileofcirculatingmethylargininesinobesepatientsresultsfromapilotstudy AT chloecloteau bariatricsurgeryimprovestheatherogenicprofileofcirculatingmethylargininesinobesepatientsresultsfromapilotstudy AT audreyaguesse bariatricsurgeryimprovestheatherogenicprofileofcirculatingmethylargininesinobesepatientsresultsfromapilotstudy AT xavierbillot bariatricsurgeryimprovestheatherogenicprofileofcirculatingmethylargininesinobesepatientsresultsfromapilotstudy AT etiennethevenot bariatricsurgeryimprovestheatherogenicprofileofcirculatingmethylargininesinobesepatientsresultsfromapilotstudy AT michelkrempf bariatricsurgeryimprovestheatherogenicprofileofcirculatingmethylargininesinobesepatientsresultsfromapilotstudy AT renevalero bariatricsurgeryimprovestheatherogenicprofileofcirculatingmethylargininesinobesepatientsresultsfromapilotstudy AT mariemaraninchi bariatricsurgeryimprovestheatherogenicprofileofcirculatingmethylargininesinobesepatientsresultsfromapilotstudy AT mikaelcroyal bariatricsurgeryimprovestheatherogenicprofileofcirculatingmethylargininesinobesepatientsresultsfromapilotstudy
_version_	1718411303361445888

Bariatric Surgery Improves the Atherogenic Profile of Circulating Methylarginines in Obese Patients: Results from a Pilot Study

Ejemplares similares